Sugi Predict

Sugi Predict / Compounds / SCHEMBL5408071

SCHEMBL5408071

SCHEMBL5408071

CCCCC(CC)COC(=O)/C(C#N)=C\c1ccc(NC(C)=O)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 3/20 0.53
▸ ALDH1A1 P00352 9/20 0.49
▸ LMNA P02545 4/20 0.49
▸ RAB9A P51151 2/20 0.49
▸ MAPK1 P28482 2/20 0.49
▸ HPGD P15428 2/20 0.47
▸ KMT2A Q03164 2/20 0.44
▸ MAPT P10636 5/20 0.44
▸ TDP1 Q9NUW8 2/20 0.43
▸ CA2 P00918 1/20 0.42
▸ CYP3A4 P08684 1/20 0.42
▸ MEN1 O00255 1/20 0.41
▸ NPC1 O15118 1/20 0.41
▸ CASP3 P42574 1/20 0.41
▸ SENP8 Q96LD8 1/20 0.41
▸ SENP7 Q9BQF6 1/20 0.41
▸ SENP6 Q9GZR1 1/20 0.41
▸ L3MBTL1 Q9Y468 1/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.41
▸ PKM P14618 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4815087 1.00 KDM4E (0.53) KDM4EALDH1A1LMNARAB9AMAPK1
SCHEMBL4815079 1.00 KDM4E (0.53) KDM4EALDH1A1LMNARAB9AMAPK1
SCHEMBL14163363 0.91 ALDH1A1 (0.48) KDM4EALDH1A1LMNARAB9AMAPK1
SCHEMBL10644154 0.90 ALDH1A1 (0.58) KDM4EALDH1A1LMNARAB9AMAPK1
SCHEMBL14400776 0.89 ALDH1A1 (0.46) KDM4EALDH1A1LMNARAB9AMAPK1
SCHEMBL4807659 0.89 ALDH1A1 (0.47) KDM4EALDH1A1LMNARAB9AMAPK1
SCHEMBL4807663 0.89 ALDH1A1 (0.47) KDM4EALDH1A1LMNARAB9AMAPK1
SCHEMBL14163398 0.89 ALDH1A1 (0.47) KDM4EALDH1A1LMNARAB9AMAPK1
SCHEMBL4813060 0.88 ALDH1A1 (0.50) KDM4EALDH1A1LMNARAB9AMAPK1
SCHEMBL4813058 0.88 ALDH1A1 (0.50) KDM4EALDH1A1LMNARAB9AMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7166274-B2 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds L'OREAL (FR) 2007-01-23 — — US claimed
US-20040047820-A1 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds SOCIETE L'OREAL S.A. (FR) 2004-03-11 — — US claimed
US-6627180-B2 Particles having protection factor UV-APPD and an amino substituted 2-hydroxybenzophenone SOCIETE L'OREAL S.A. (FR) 2003-09-30 — — US claimed
US-20030152532-A1 SYNERGISTICALLY UV-PHOTOPROTECTING COMPOSITIONS COMPRISING MIXED SCREENING AGENTS SOCIETE L'OREAL S.A. (FR) 2003-08-14 — — US claimed
EP-3709966-B1 COMPOSITIONS COMPRISING AT LEAST ONE ACRYLIC POLYMER AND AT LEAST ONE INSOLUBLE ORGANIC SCREENING AGENT OREAL (FR) 2024-12-11 — — EP disclosed
US-20210346249-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER L'OREAL (FR) 2021-11-11 — — US disclosed
US-20200360264-A1 COMPOSITIONS COMPRISING AT LEAST ONE ACRYLIC POLYMER AND AT LEAST ONE INSOLUBLE ORGANIC SCREENING AGENT L'OREAL (FR) 2020-11-19 — — US disclosed
EP-3709966-A1 COMPOSITIONS COMPRISING AT LEAST ONE ACRYLIC POLYMER AND AT LEAST ONE INSOLUBLE ORGANIC SCREENING AGENT L'Oreal (FR) 2020-09-23 — — EP disclosed
US-20200030200-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER L'OREAL (FR) 2020-01-30 — — US disclosed
EP-3307233-B1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER OREAL (FR) 2019-11-06 — — EP disclosed
EP-3307233-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER L'Oréal (FR) 2018-04-18 — — EP disclosed
US-20170326045-A1 COSMETIC COMPOSITION COMPRISING A SYNTHETIC PHYLLOSILICATE AND A POLYOL AND/OR A UV FILTER L'OREAL (FR) 2017-11-16 — — US disclosed
US-20170304658-A1 GEL/GEL COMPOSITION COMPRISING A UV-SCREENING AGENT L'OREAL (FR) 2017-10-26 — — US disclosed
WO-2016198581-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER L'OREAL (FR) 2016-12-15 — — WO disclosed
US-20150157539-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE PARTICLES L'OREAL (FR) 2015-06-11 — — US disclosed
US-7166274-B2 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds L'OREAL (FR) 2007-01-23 — — US disclosed
US-20040047820-A1 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds SOCIETE L'OREAL S.A. (FR) 2004-03-11 — — US disclosed
US-6627180-B2 Particles having protection factor UV-APPD and an amino substituted 2-hydroxybenzophenone SOCIETE L'OREAL S.A. (FR) 2003-09-30 — — US disclosed
US-20030152532-A1 SYNERGISTICALLY UV-PHOTOPROTECTING COMPOSITIONS COMPRISING MIXED SCREENING AGENTS SOCIETE L'OREAL S.A. (FR) 2003-08-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200360264-A1 COMPOSITIONS COMPRISING AT LEAST ONE ACRYLIC POLYMER AND AT LEAST ONE INSOLUBLE ORGANIC SCREENING AGENT PCNA, ERCC1, XRCC6 KDM4E 4068/4885ALDH1A1 683/4885LMNA 924/4885
US-20040047820-A1 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds SUCLG1, CUTA, DLD KDM4E 1942/4885ALDH1A1 246/4885LMNA 2544/4885
US-20170326045-A1 COSMETIC COMPOSITION COMPRISING A SYNTHETIC PHYLLOSILICATE AND A POLYOL AND/OR A UV FILTER PUF60, POLR1C, DPM1 KDM4E 1937/4885ALDH1A1 3241/4885LMNA 2324/4885
US-20150157539-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE PARTICLES MITF, RAB5IF, TYR KDM4E 3078/4885ALDH1A1 281/4885LMNA 683/4885
US-20200030200-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER ERCC5, CUTA, PLIN5 KDM4E 2944/4885ALDH1A1 3802/4885LMNA 77/4885
US-20170304658-A1 GEL/GEL COMPOSITION COMPRISING A UV-SCREENING AGENT CUTA, KRT18, APOL1 KDM4E 2398/4885ALDH1A1 2912/4885LMNA 31/4885
US-20210346249-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER ERCC5, CUTA, PLIN5 KDM4E 2944/4885ALDH1A1 3802/4885LMNA 77/4885
US-20030152532-A1 SYNERGISTICALLY UV-PHOTOPROTECTING COMPOSITIONS COMPRISING MIXED SCREENING AGENTS HADHB, SDHA, ERCC4 KDM4E 3030/4885ALDH1A1 193/4885LMNA 1825/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.