D-Glutamate

D-Glutamate

SCHEMBL1897914

N[C@@H](CCC(=O)[O-])C(=O)[O-].[H+].[Na+]

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 known ✓ P00915 3/20 0.50
CA2 known ✓ P00918 2/20 0.39
CA4 known ✓ P22748 1/20 0.36
FOLH1 Q04609 2/20 0.42
BBOX1 O75936 1/20 0.40
GRM8 O00222 1/20 0.39
GRM6 O15303 1/20 0.39
GRIN2D O15399 1/20 0.39
GRIN3B O60391 1/20 0.39
GSR P00390 1/20 0.39
CYP1A2 P05177 1/20 0.39
GRIK1 P39086 1/20 0.39
GRM5 P41594 1/20 0.39
GRIA1 P42261 1/20 0.39
GRIA2 P42262 1/20 0.39
GRIA3 P42263 1/20 0.39
SLC1A3 P43003 1/20 0.39
SLC1A2 P43004 1/20 0.39
SLC1A1 P43005 1/20 0.39
GRIA4 P48058 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
D-Glutamate SCHEMBL1518007 1.00 CA1 (0.50) CA1FOLH1BBOX1CA2GRM8
D-Glutamate SCHEMBL18880 0.98 CA1 (0.52) CA1FOLH1BBOX1CA2GRM8
D-Glutamate SCHEMBL541429 0.98 CA1 (0.52) CA1FOLH1BBOX1CA2GRM8
D-Glutamate SCHEMBL16335 0.98 CA1 (0.52) CA1FOLH1BBOX1CA2GRM8
D-Glutamate SCHEMBL330960 0.98 CA1 (0.52) CA1FOLH1BBOX1CA2GRM8
D-Glutamate SCHEMBL330961 0.98 CA1 (0.52) CA1FOLH1BBOX1CA2GRM8
D-Glutamate SCHEMBL757896 0.98 CA1 (0.48) CA1FOLH1BBOX1CA2GRM8
D-Glutamate SCHEMBL2853212 0.95 CA1 (0.50) CA1FOLH1BBOX1CA2GRM8
D-Glutamate SCHEMBL1301472 0.95 CA1 (0.46) CA1FOLH1BBOX1CA2GRM8
D-Glutamate SCHEMBL1899057 0.95 CA1 (0.46) CA1FOLH1BBOX1CA2GRM8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3395862-B1 RESIN COMPOSITION PELLETS MITSUBISHI CHEM CORP (JP) 2023-05-10 EP disclosed
US-10358533-B2 Resin composition pellet MITSUBISHI CHEMICAL CORPORATION (JP) 2019-07-23 US disclosed
US-20180371179-A1 RESIN COMPOSITION PELLET THE NIPPON SYNTHETIC CHEMICAL INDUSTRY CO., LTD. (JP) 2018-12-27 US disclosed
EP-3395862-A1 RESIN COMPOSITION PELLETS The Nippon Synthetic Chemical Industry Co., Ltd. (JP) 2018-10-31 EP disclosed
EP-2845881-B1 RESIN COMPOSITION, MELT FORMED ARTICLE, MULTILAYER STRUCTURE, AND PROCESS FOR PRODUCING RESIN COMPOSITION NIPPON SYNTHETIC CHEM IND CO LTD (JP) 2018-04-11 EP disclosed
EP-2322578-B1 RESIN COMPOSITION, MELT FORMED ARTICLE, MULTILAYER STRUCTURE, AND PROCESS FOR PRODUCING RESIN COMPOSITION NIPPON SYNTHETIC CHEM IND CO LTD (JP) 2017-09-20 EP disclosed
US-9376545-B2 Resin composition, melt-formed article, multilayer structure, and process for producing resin composition THE NIPPON SYNTHETIC CHEMICAL INDUSTRY CO., LTD. (JP) 2016-06-28 US disclosed
EP-2845881-A1 Resin composition, melt formed article, multilayer structure, and process for producing resin composition The Nippon Synthetic Chemical Industry Co., Ltd. (JP) 2015-03-11 EP disclosed
US-20110135950-A1 RESIN COMPOSITION, MELT-FORMED ARTICLE, MULTILAYER STRUCTURE, AND PROCESS FOR PRODUCING RESIN COMPOSITION THE NIPPON SYNTHETIC CHEMICAL INDUSTRY CO., LTD., (JP) 2011-06-09 US disclosed
EP-2322578-A1 RESIN COMPOSITION, MELT-MOLDED ARTICLE, MULTI-LAYERED STRUCTURE, AND PROCESS FOR PRODUCTION OF RESIN COMPOSITION The Nippon Synthetic Chemical Industry Co., Ltd. (JP) 2011-05-18 EP disclosed