Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5474346 | 0.81 | PDE4B (0.46) | ALDH1A1NPSR1POLBPDE4BPDE4D | |
| SCHEMBL5474495 | 0.80 | POLB (0.46) | ALDH1A1POLBPDE4BPDE4DMEN1 | |
| SCHEMBL5471801 | 0.79 | POLB (0.48) | ALDH1A1POLBPDE4BPDE4DMEN1 | |
| SCHEMBL5476172 | 0.79 | MEN1 (0.43) | ALDH1A1NPSR1POLBPDE4BPDE4D | |
| SCHEMBL5467459 | 0.77 | LMNA (0.47) | POLBPDE4BPDE4DMEN1LMNA | |
| SCHEMBL10212057 | 0.75 | ALDH1A1 (0.58) | ALDH1A1NPSR1NPC1RAB9APOLB | |
| SCHEMBL5477116 | 0.74 | PTGS2 (0.45) | ALDH1A1NPC1RAB9APOLBMEN1 | |
| SCHEMBL5470932 | 0.74 | MAPT (0.43) | ALDH1A1NPSR1NPC1RAB9APOLB | |
| SCHEMBL5476920 | 0.74 | ALDH1A1 (0.43) | ALDH1A1NPC1RAB9APOLBPDE4B | |
| SCHEMBL5470986 | 0.72 | RORC (0.43) | ALDH1A1NPC1RAB9APOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161637-A1 | Substituted pyridin-2-ylamine analogues | NEUROGEN CORPORATION (US) | 2007-07-12 | — | — | US | claimed |
| EP-1648877-A1 | SUBSTITUTED PYRIDIN-2-YLAMINE ANALOGUES | NEUROGEN CORPORATION (US) | 2006-04-26 | — | — | EP | claimed |
| WO-2005009980-A1 | SUBSTITUTED PYRIDIN-2-YLAMINE ANALOGUES | NEUROGEN CORPORATION (US) | 2005-02-03 | — | — | WO | claimed |
| US-20070161637-A1 | Substituted pyridin-2-ylamine analogues | NEUROGEN CORPORATION (US) | 2007-07-12 | — | — | US | disclosed |
| US-20070161637-A1 | Substituted pyridin-2-ylamine analogues | NEUROGEN CORPORATION (US) | 2007-07-12 | — | — | US | disclosed |
| US-20070161637-A1 | Substituted pyridin-2-ylamine analogues | NEUROGEN CORPORATION (US) | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161637-A1 | Substituted pyridin-2-ylamine analogues | PIGS, GPR35, GPR174 | ALDH1A1 1296/4885NPSR1 182/4885NPC1 3482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.