SCHEMBL5482338

SCHEMBL5482338

CC(=O)O[C@@H](C)C(=O)Nc1c(I)c(C(=O)Cl)c(I)c(C(=O)Cl)c1I

nearest known ligand 0.40

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.40
ALDH1A1 P00352 1/20 0.32
TSHR P16473 1/20 0.31
KLK7 P49862 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6879887 1.00 LMNA (0.40) LMNAALDH1A1TSHRKLK7
SCHEMBL5356462 1.00 LMNA (0.40) LMNAALDH1A1TSHRKLK7
SCHEMBL9191546 0.92 LMNA (0.40) LMNA
SCHEMBL22661219 0.92 LMNA (0.34) LMNAALDH1A1
SCHEMBL25813346 0.89 LMNA (0.35) LMNA
SCHEMBL14181569 0.88 LMNA (0.41) LMNAALDH1A1TSHRKLK7
SCHEMBL9260881 0.87 LMNA (0.62) LMNA
SCHEMBL9353070 0.87 LMNA (0.42) LMNA
SCHEMBL8978138 0.87 LMNA (0.62) LMNA
SCHEMBL7581413 0.86 LMNA (0.42) LMNATSHRKLK7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2723709-B1 MANUFACTURE OF A TRIIODINATED CONTRAST AGENT HOVIONE INT LTD (CH) 2015-09-09 EP claimed
US-8835672-B2 Manufacture of a triiodinated contrast agent HOVIONE INTER LIMITED (CH) 2014-09-16 US claimed
US-20140155648-A1 Manufacture of a Triiodinated Contrast Agent HOVIONE INTER LIMITED (CH) 2014-06-05 US claimed
EP-1075462-B1 PROCESS FOR THE PREPARATION OF S- N,N'- BIS[2- HYDROXY-1- (HYDROXYMETHYL) ETHYL]-5- [(2- HYDROXY-1- OXOPROPYL)- AMINO]- 2,4,6- TRIIODO- 1,3- BENZENEDICARBOXAMIDE BRACCO IMAGING SPA (IT) 2003-06-25 EP claimed
EP-1112247-B1 A PROCESS FOR THE PREPARATION OF S-N,N'-BIS 2-HYDROXY-1- (HYDROXYMETHYL) ETHYL]-5- (2-HYDROXY-1- OXOPROPYL) AMINO]-2,4,6- TRIIODO-1,3- BENZENEDICARBOXAMIDE BRACCO IMAGING SPA (IT) 2003-04-16 EP claimed
EP-0901460-B1 A PROCESS FOR THE PREPARATION OF 5-AMINO-2,4,6-TRIIODO-1,3-BENZENEDICARBOXYLIC ACID DERIVATIVES BRACCO IMAGING SPA (IT) 2002-09-18 EP claimed
US-6350908-B1 MULTISTAGE REACTION WITH AMIDATION OF ACYL HALIDES WITH AMINOALKANEDIOLS AND HYDROLYSIS BRACCO IMAGING S.P.A (IT) 2002-02-26 US claimed
EP-0851854-B1 PROCESS FOR THE PURIFICATION OF AN INTERMEDIATE IN THE PREPARATION OF IOPAMIDOL BRACCO IMAGING SPA (IT) 2001-12-12 EP claimed
US-6262303-B1 FROM THE COORRESPONDING DIACID CHLORIDE WITH 2-AMINO-1,3-PROPANEDIOL IN SOLVENT DIBRA S.P.A. (IT) 2001-07-17 US claimed
EP-1075462-A2 PROCESS FOR THE PREPARATION OF S- N,N'- BIS[2- HYDROXY-1- (HYDROXYMETHYL) ETHYL]-5- [(2- HYDROXY-1- OXOPROPYL)- AMINO]- 2,4,6- TRIIODO- 1,3- BENZENEDICARBOXAMIDE BRACCO IMAGING S.p.A. (IT) 2001-02-14 EP claimed
EP-0773925-B1 PROCESS FOR THE PREPARATION OF A DICARBOXYLIC ACID DICHLORIDE FRUCTAMINE SPA (IT) 2000-02-09 EP claimed
WO-1999058494-A2 PROCESS FOR THE PREPARATION OF S- N,N'- BIS[2- HYDROXY-1- (HYDROXYMETHYL) ETHYL]-5- [(2- HYDROXY-1- OXOPROPYL)- AMINO]- 2,4,6- TRIIODO- 1,3- BENZENEDICARBOXAMIDE DIBRA S.P.A. (IT) 1999-11-18 WO claimed
WO-2023117667-A1 PROCESS FOR THE PREPARATION OF 2,4,6-TRIIODOISOPHTHALIC BISAMIDES BRACCO IMAGING SPA (IT) 2023-06-29 WO disclosed
EP-3580199-B1 METHOD FOR THE ONE-POT PRODUCTION OF ORGANO-IODINATED COMPOUNDS GUERBET SA (FR) 2023-04-05 EP disclosed
US-10836711-B2 Method for the one-pot production of organo-iodinated compounds GUERBET (FR) 2020-11-17 US disclosed
US-10738000-B2 Method for the preparation of (S)-2-acetyloxypropionic acid and derivatives thereof BRACCO IMAGING SPA (IT) 2020-08-11 US disclosed
WO-1996037460-A1 PROCESS FOR THE PREPARATION OF A DICARBOXYLIC ACID DICHLORIDE FRUCTAMINE S.P.A. (IT) 1996-11-28 WO disclosed
EP-0707572-A1 IODINATED OLIGOMERIC COMPOUNDS AND DIAGNOSTIC COMPOSITIONS CONTAINING THE SAME BRACCO S.p.A. (IT) 1996-04-24 EP disclosed
WO-1995001966-A1 IODINATED OLIGOMERIC COMPOUNDS AND DIAGNOSTIC COMPOSITIONS CONTAINING THE SAME BRACCO S.P.A. (IT) 1995-01-19 WO disclosed
US-4364921-A RADIOPACITY SCHERING, AKTIENGESELLSCHAFT (DE) 1982-12-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10836711-B2 Method for the one-pot production of organo-iodinated compounds TPO, NISCH, PPIP5K2 LMNA 3525/4885ALDH1A1 2138/4885TSHR 57/4885
US-10738000-B2 Method for the preparation of (S)-2-acetyloxypropionic acid and derivatives thereof LDHA, ACACA, ADSL LMNA 467/4885ALDH1A1 50/4885TSHR 3843/4885
US-20140155648-A1 Manufacture of a Triiodinated Contrast Agent SAT1, LYPLA2, AGPAT5 LMNA 2871/4885ALDH1A1 319/4885TSHR 113/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.