SCHEMBL5488878

SCHEMBL5488878

CC(C[Si](Cl)(Cl)Cl)c1ccc(Oc2ccccc2)cc1

nearest known ligand 0.60

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 7/20 0.43
TSHR P16473 1/20 0.41
ACACB O00763 1/20 0.41
ACACA Q13085 1/20 0.41
MMP9 P14780 1/20 0.39
SRD5A2 P31213 1/20 0.39
FAAH O00519 1/20 0.39
MGLL Q99685 1/20 0.39
FFAR1 O14842 1/20 0.39
NR1H2 P55055 1/20 0.38
BAX Q07812 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5413664 0.83 TAAR1 (0.52) TSHR
SCHEMBL5490777 0.80 GRIA4 (0.46)
SCHEMBL10162228 0.78 ALDH1A1 (0.54) LTA4HTSHRACACBACACANR1H2
SCHEMBL5490996 0.77 SLC6A4 (0.44) LTA4HTSHR
SCHEMBL9091135 0.76 LTA4H (0.43) LTA4HTSHRACACBACACASRD5A2
SCHEMBL5490217 0.75 IDO1 (0.38)
SCHEMBL19736611 0.75 LTA4H (0.52) LTA4HTSHRACACBACACA
SCHEMBL11489544 0.74 LTA4H (0.50) LTA4H
SCHEMBL5544471 0.74 LTA4H (0.44) LTA4HTSHRACACBACACASRD5A2
SCHEMBL5484319 0.74 ADRB2 (0.46) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7291747-B2 Silicon compounds and process for preparation thereof CHISSO CORPORATION (JP) 2007-11-06 US disclosed
US-20040143081-A1 Novel silicon compounds and process for preparation thereof JNC CORPORATION (JP) 2004-07-22 US disclosed