Bromide

Bromide

SCHEMBL5500591

Br.CCCCCCCCCCCCCCOC(N)(CC)OCCCCCCCCCCCCCC

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 9/20 0.39
CA2 P00918 9/20 0.39
CA9 Q16790 8/20 0.39
LPAR3 Q9UBY5 3/20 0.39
CA12 O43570 3/20 0.39
CA7 P43166 3/20 0.39
CA14 Q9ULX7 3/20 0.39
LPAR1 Q92633 2/20 0.39
LPAR2 Q9HBW0 2/20 0.39
CA3 P07451 2/20 0.39
CA4 P22748 2/20 0.39
CA6 P23280 2/20 0.39
CA5A P35218 2/20 0.39
CA5B Q9Y2D0 2/20 0.39
DNM1 Q05193 2/20 0.39
SMPD1 P17405 2/20 0.37
THRB P10828 2/20 0.36
TSHR P16473 1/20 0.36
MEN1 O00255 1/20 0.35
HTT P42858 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL18394656 1.00 CA1 (0.39) CA1CA2CA9LPAR3CA12
SCHEMBL10626082 0.98 CA1 (0.40) CA1CA2CA9LPAR3CA12
SCHEMBL28644993 0.98 CA1 (0.40) CA1CA2CA9LPAR3CA12
SCHEMBL28468879 0.98 CA1 (0.40) CA1CA2CA9LPAR3CA12
SCHEMBL1817037 0.98 CA1 (0.40) CA1CA2CA9LPAR3CA12
SCHEMBL9124098 0.88 ADRB2 (0.43) CA1CA2CA9SMPD1TSHR
Bromide SCHEMBL29050094 0.87 GBA1 (0.38) LPAR3LPAR1LPAR2DNM1SMPD1
SCHEMBL27094088 0.86 LPAR3 (0.46) LPAR3LPAR1LPAR2MEN1KMT2A
SCHEMBL8440337 0.78 DNM1 (0.46) CA1CA2CA9CA12CA7
SCHEMBL6928943 0.78 CA1 (0.31) CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1766094-A2 INFLUENZA VIRUS VACCINE COMPOSITION AND METHOD OF USE Vical Incorporated (US) 2007-03-28 EP claimed
EP-1575505-A4 CODON-OPTIMIZED POLYNUCLEOTIDE-BASED VACCINES AGAINST BACILLUS ANTHRACIS INFECTION VICAL INC (US) 2007-01-24 EP claimed
WO-2005116270-A2 INFLUENZA VIRUS VACCINE COMPOSITION AND METHOD OF USE VICAL INCORPORATED (US) 2005-12-08 WO claimed
EP-1575505-A2 CODON-OPTIMIZED POLYNUCLEOTIDE-BASED VACCINES AGAINST BACILLUS ANTHRACIS INFECTION Vical Incorporated (US) 2005-09-21 EP claimed
EP-1575505-A3 CODON-OPTIMIZED POLYNUCLEOTIDE-BASED VACCINES AGAINST BACILLUS ANTHRACIS INFECTION Vical Incorporated (US) 2005-09-01 EP claimed
WO-2004024067-A2 CODON-OPTIMIZED POLYNUCLEOTIDE-BASED VACCINES AGAINST BACILLUS ANTHRACIS INFECTION VICAL INCORPORATED (US) 2004-03-25 WO claimed
US-20250376674-A1 SPLIT PRIME EDITORS PRIME MEDICINE INC (US) 2025-12-11 US disclosed
US-12454694-B2 Compositions and methods for improving base editing BEAM THERAPEUTICS INC. (US) 2025-10-28 US disclosed
US-20250179483-A1 GENOME EDITING COMPOSITIONS AND METHODS FOR TREATMENT OF GLYCOGEN STORAGE DISEASE TYPE 1B PRIME MEDICINE, INC. 2025-06-05 US disclosed
US-20250073352-A1 GENOME EDITING COMPOSITIONS AND METHODS FOR TREATMENT OF FRAGILE X SYNDROME PRIME MEDICINE, INC. 2025-03-06 US disclosed
US-20240417706-A1 SYSTEMS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES EDITAS MEDICINE, INC. (US) 2024-12-19 US disclosed
US-20240352453-A1 GENOME EDITING COMPOSITIONS AND METHODS FOR TREATMENT OF RETINOPATHY PRIME MEDICINE, INC. 2024-10-24 US disclosed
US-20240301405-A1 GUIDE RNAS FOR CRISPR/CAS EDITING SYSTEMS BEAM THERAPEUTICS INC. 2024-09-12 US disclosed
US-10006054-B1 Systems and methods for one-shot guide RNA (ogRNA) targeting of endogenous and source DNA EDITAS MEDICINE, INC. (US) 2018-06-26 US disclosed
US-20180119123-A1 CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING HIV INFECTION AND AIDS EDITAS MEDICINE, INC. (US) 2018-05-03 US disclosed
WO-2017075475-A1 CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING HERPES SIMPLEX VIRUS EDITAS MEDICINE, INC. (US) 2017-05-04 WO disclosed
US-20170029850-A1 CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING PRIMARY OPEN ANGLE GLAUCOMA EDITAS MEDICINE, INC. 2017-02-02 US disclosed
US-20170022507-A1 CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING CYSTIC FIBROSIS EDITAS MEDICINE, INC. (US) 2017-01-26 US disclosed
EP-1278551-A2 COMPOSITIONS AND METHODS FOR (IN VIVO) DELIVERY OF POLYNUCLEOTIDE-BASED THERAPEUTICS VICAL INCORPORATED (US) 2003-01-29 EP disclosed
WO-2001080897-A2 COMPOSITIONS AND METHODS FOR IN VIVO DELIVERY OF POLYNUCLEOTIDE-BASED THERAPEUTICS VICAL INCORPORATED (US) 2001-11-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240301405-A1 GUIDE RNAS FOR CRISPR/CAS EDITING SYSTEMS NSUN3, ZFR, NARS1 CA1 4271/4885CA2 4621/4885CA9 4042/4885
US-20180119123-A1 CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING HIV INFECTION AND AIDS CCR5, CXCR4, CXCR3 CA1 4519/4885CA2 3285/4885CA9 2430/4885
US-20170029850-A1 CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING PRIMARY OPEN ANGLE GLAUCOMA UACA, CRYAA, CRYAB CA1 3988/4885CA2 184/4885CA9 168/4885
US-20240417706-A1 SYSTEMS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES HBG2, HBG1, HBB CA1 4705/4885CA2 3824/4885CA9 4171/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.