Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12489727 | 0.98 | HPGD (0.62) | HPGDGAAMEN1KMT2ACYP2C9 | |
| SCHEMBL12018338 | 0.90 | CES2 (0.56) | HPGDGAAMEN1KMT2ACYP2C9 | |
| SCHEMBL28916549 | 0.87 | HPGD (0.69) | HPGDMEN1KMT2ACYP2C9ALDH1A1 | |
| SCHEMBL29738490 | 0.85 | HPGD (0.58) | HPGDGAAMEN1KMT2ACYP2C9 | |
| SCHEMBL23564897 | 0.82 | HPGD (0.58) | HPGDGAAMEN1KMT2ACYP2C9 | |
| SCHEMBL19380449 | 0.81 | PHGDH (0.70) | HPGDGAAMEN1KMT2ACYP2C9 | |
| SCHEMBL19987424 | 0.81 | HPGD (0.61) | HPGDGAAMEN1KMT2ACYP2C9 | |
| SCHEMBL14453332 | 0.81 | HPGD (0.61) | HPGDGAAMEN1KMT2ACYP2C9 | |
| SCHEMBL28916572 | 0.81 | HPGD (0.65) | HPGDKMT2AALDH1A1USP2LMNA | |
| SCHEMBL8566690 | 0.81 | HPGD (0.62) | HPGDGAAKMT2ACYP2C9POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017077550-A1 | A METAL FREE PROCESS FOR THE PREPARATION OF ALPHA-SUBSTITUTED CARBONYL COMPOUNDS FROM ALKENES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-11 | — | — | WO | claimed |
| EP-0635004-B1 | 4-DIPHENYLMETHYL PIPERIDINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | MERRELL PHARMA INC (US) | 2002-07-17 | — | — | EP | claimed |
| CN-1275977-A | Heterocyclic thioesters and ketones | GPI NIL HOLDING CO (US) | 2000-12-06 | — | — | CN | claimed |
| CN-113248458-B | Preparation method of alpha-carbonyl amide compound | 陕西省煤田地质集团有限公司 | 2022-09-27 | — | — | CN | disclosed |
| CN-113248458-A | Preparation method of alpha-carbonyl amide compound | 陕西省煤田地质集团有限公司 | 2021-08-13 | — | — | CN | disclosed |
| WO-2018050546-A1 | IMPROVEMENTS IN OR RELATING TO ORGANIC MATERIAL | Université de Liège (BE) | 2018-03-22 | — | — | WO | disclosed |
| WO-2018050546-A1 | IMPROVEMENTS IN OR RELATING TO ORGANIC MATERIAL | Université de Liège (BE) | 2018-03-22 | — | — | WO | disclosed |
| EP-3296292-A1 | METHOD FOR THE PREPARATION OF ALKYL PHENIDATES | Université de Liège (BE) | 2018-03-21 | — | — | EP | disclosed |
| EP-3296292-A1 | METHOD FOR THE PREPARATION OF ALKYL PHENIDATES | Université de Liège (BE) | 2018-03-21 | — | — | EP | disclosed |
| WO-2017077550-A1 | A METAL FREE PROCESS FOR THE PREPARATION OF ALPHA-SUBSTITUTED CARBONYL COMPOUNDS FROM ALKENES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-11 | — | — | WO | disclosed |
| CN-104529686-B | One utilizes aryl ester and amide to react to prepare asymmetric acid imide | 内蒙古师范大学 | 2016-06-29 | — | — | CN | disclosed |
| US-7247730-B2 | Process for the preparation of dexmethylphenidate hydrochloride | ISP INVESTMENTS INC. (US) | 2007-07-24 | — | — | US | disclosed |
| US-7247730-B2 | Process for the preparation of dexmethylphenidate hydrochloride | ISP INVESTMENTS INC. (US) | 2007-07-24 | — | — | US | disclosed |
| CN-1285575-C | Heterocyclic thioesters and ketones | GPI NIL HOLDING CO (US) | 2006-11-22 | — | — | CN | disclosed |
| US-7002016-B2 | Process for the preparation of threo-methylphenidate hydrochloride | ISP INVESTMENTS INC. (US) | 2006-02-21 | — | — | US | disclosed |
| WO-2004080583-A2 | PROCESS FOR THE PREPARATION OF threo-METHYLPHENIDATE HYDROCHLORIDE | ISP INVESTMENTS INC. (US) | 2004-09-23 | — | — | WO | disclosed |
| WO-2004080959-A2 | PROCESS FOR THE PREPARATION OF DEXMETHYLPHENIDATE HYDROCHLORIDE | ISP INVESTMENTS INC. (US) | 2004-09-23 | — | — | WO | disclosed |
| US-20040180928-A1 | Process for the preparation of dexmethylphenidate hydrochloride | ISP INVESTMENTS INC. | 2004-09-16 | — | — | US | disclosed |
| US-20040176412-A1 | Process for the preparation of threo-methylphenidate hydrochloride | ISP INVESTMENTS INC. | 2004-09-09 | — | — | US | disclosed |
| CN-1275977-A | Heterocyclic thioesters and ketones | GPI NIL HOLDING CO (US) | 2000-12-06 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176412-A1 | Process for the preparation of threo-methylphenidate hydrochloride | COMT, METTL3, SLC6A3 | HPGD 4202/4885GAA 665/4885MEN1 4800/4885 |
| US-20040180928-A1 | Process for the preparation of dexmethylphenidate hydrochloride | HTR1A, HTR6, COMT | HPGD 3854/4885GAA 92/4885MEN1 4043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.