SCHEMBL5567676

SCHEMBL5567676

S=c1[nH]nc(-c2ccccc2)o1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 1.00
KDM4E B2RXH2 2/20 1.00
PPARG P37231 2/20 1.00
NCOA2 Q15596 2/20 1.00
NCOA1 Q15788 2/20 1.00
RXFP1 Q9HBX9 2/20 1.00
HPGD P15428 1/20 1.00
TDP1 Q9NUW8 1/20 1.00
TYMP P19971 1/20 0.69
HSD17B10 Q99714 1/20 0.66
POLB P06746 1/20 0.64
NOTUM Q6P988 1/20 0.60
MEN1 O00255 1/20 0.59
KMT2A Q03164 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13984125 0.96 ALDH1A1 (0.92) ALDH1A1KDM4EPPARGNCOA2NCOA1
SCHEMBL17065364 0.82 ALDH1A1 (0.69) ALDH1A1KDM4EPPARGNCOA2NCOA1
SCHEMBL11862484 0.80 TYMP (0.70) ALDH1A1KDM4EPPARGNCOA2NCOA1
SCHEMBL30594886 0.80 TYMP (0.70) ALDH1A1KDM4EPPARGNCOA2NCOA1
SCHEMBL21144405 0.80 ALDH1A1 (1.00) ALDH1A1KDM4EPPARGNCOA2NCOA1
SCHEMBL4789246 0.78 NOTUM (0.67) ALDH1A1KDM4EPPARGNCOA2NCOA1
SCHEMBL29245313 0.77 ALDH1A1 (0.60) ALDH1A1KDM4EPPARGNCOA2NCOA1
SCHEMBL4238963 0.76 MEN1 (1.00) ALDH1A1KDM4EPPARGNCOA2NCOA1
SCHEMBL13984128 0.76 NOTUM (0.66) ALDH1A1KDM4EPPARGNCOA2NCOA1
SCHEMBL13984124 0.76 NOTUM (0.66) ALDH1A1KDM4EPPARGNCOA2NCOA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 504 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-1283278-A None JP disclosed
CN-119816495-A 1,3, 4-Oxadiazole derivative compounds as histone deacetylase 6 inhibitors and uses thereof 株式会社钟根堂 2025-04-11 CN disclosed
EP-4398254-A2 COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING Memorial Sloan Kettering Cancer Center (US) 2024-07-10 EP disclosed
US-12023371-B2 Terminally modified RNA MODERNATX, INC. (US) 2024-07-02 US disclosed
US-20240165267-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF ARES CAPITAL CORPORATION, AS AGENT 2024-05-23 US disclosed
US-11987590-B2 Compounds that participate in cooperative binding and uses thereof Revolution Medicines, Inc. (US) 2024-05-21 US disclosed
US-11981703-B2 Polynucleotide constructs SIRIUS THERAPEUTICS, INC. (US) 2024-05-14 US disclosed
US-20240131193-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND CYTOSKELETAL PROTEINS ARES CAPITAL CORPORATION, AS AGENT 2024-04-25 US disclosed
US-20240123035-A1 MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS ARES CAPITAL CORPORATION, AS AGENT 2024-04-18 US disclosed
EP-4351662-A1 RADIOIMMUNOCONJUGATES AND CHECKPOINT INHIBITOR COMBINATION THERAPY Fusion Pharmaceuticals Inc. (CA) 2024-04-17 EP disclosed
WO-2013052523-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF modeRNA Therapeutics (US) 2013-04-11 WO disclosed
EP-1000040-B1 IL-5 INHIBITING 6-AZAURACIL DERIVATIVES JANSSEN PHARMACEUTICA NV (BE) 2007-06-13 EP disclosed
US-20050090495-A1 Novel IL-5 inhibiting 6-azauracil derivatives for marking and identifying receptors and imaging organs LACRAMPE JEAN FERNAND ARMAND (FR) 2005-04-28 US disclosed
US-6867207-B2 IL-5 inhibiting 6-azauracil derivatives JANSSEN PHARMACEUTICA N.V. (BE) 2005-03-15 US disclosed
US-20040167333-A1 Novel IL-5 inhibiting 6-azauracil derivatives for marking and identifying receptors and imaging organs LACRAMPE JEAN FERNAND ARMAND (FR) 2004-08-26 US disclosed
US-20020072603-A1 Novel IL-5 inhibiting 6-azauracil derivatives LACRAMPE JEAN FERNAND ARMAND (FR) 2002-06-13 US disclosed
EP-1000040-A1 IL-5 INHIBITING 6-AZAURACIL DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 2000-05-17 EP disclosed
WO-1999002505-A1 IL-5 INHIBITING 6-AZAURACIL DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1999-01-21 WO disclosed
JP-H01283278-A 4,4'-CARBONYLBIS(2-PHENYL-1,3,4-OXADIAZOLINE-5-THIONE) AND PRODUCTION THEREOF NAKAMURA SHIGEO 1989-11-14 JP disclosed
US-3971803-A DISCOLORATION INHIBITION, POLYMER STABILIZERS CIBA-GEIGY CORPORATION (US) 1976-07-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11981703-B2 Polynucleotide constructs PHAX, CPSF6, RNGTT ALDH1A1 3953/4885KDM4E 4658/4885PPARG 2961/4885
US-20040167333-A1 Novel IL-5 inhibiting 6-azauracil derivatives for marking and identifying receptors and imaging organs IL6ST, CXCR5, ALOX5 ALDH1A1 1219/4885KDM4E 3074/4885PPARG 418/4885
US-11987590-B2 Compounds that participate in cooperative binding and uses thereof CEP170, PIN1, FKBP3 ALDH1A1 4800/4885KDM4E 3972/4885PPARG 3502/4885
US-20050090495-A1 Novel IL-5 inhibiting 6-azauracil derivatives for marking and identifying receptors and imaging organs CXCR5, HCAR3, IL6ST ALDH1A1 1331/4885KDM4E 3799/4885PPARG 744/4885
US-20240165267-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 ALDH1A1 1969/4885KDM4E 3519/4885PPARG 2844/4885
US-20240131193-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND CYTOSKELETAL PROTEINS PHAX, NSUN2, RNMT ALDH1A1 4792/4885KDM4E 2455/4885PPARG 4329/4885
US-12023371-B2 Terminally modified RNA RNGTT, NSUN3, RNMT ALDH1A1 4235/4885KDM4E 495/4885PPARG 4188/4885
US-20240123035-A1 MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS NSUN2, RNMT, NSUN3 ALDH1A1 4488/4885KDM4E 4406/4885PPARG 3371/4885
US-20020072603-A1 Novel IL-5 inhibiting 6-azauracil derivatives IL6ST, ALOX5, IL5 ALDH1A1 848/4885KDM4E 2126/4885PPARG 853/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.