Sugi Predict

Sugi Predict / Compounds / SCHEMBL559815

SCHEMBL559815

SCHEMBL559815

N#Cc1cc(Br)ccc1Cl

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ VCAM1 P19320 1/20 0.48
▸ SLC1A5 Q15758 1/20 0.44
▸ TRPV4 Q9HBA0 1/20 0.42
▸ MAOB P27338 3/20 0.41
▸ MAOA P21397 2/20 0.41
▸ SLC22A12 Q96S37 4/20 0.39
▸ IDO1 P14902 1/20 0.39
▸ GRM4 Q14833 1/20 0.37
▸ MAPK14 Q16539 1/20 0.36
▸ ALDH1A1 P00352 1/20 0.36
▸ SRC P12931 1/20 0.35
▸ CHEK1 O14757 1/20 0.35
▸ MCL1 Q07820 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ MAPK1 P28482 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ MRGPRX4 Q96LA9 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30224701 1.00 VCAM1 (0.48) VCAM1SLC1A5TRPV4MAOBMAOA
SCHEMBL267151 0.82 TRPV4 (0.57) SLC1A5TRPV4MAOBMAOASLC22A12
SCHEMBL1395661 0.78 MAOB (0.61) SLC1A5MAOBMAOAALDH1A1CHEK1
SCHEMBL30475151 0.78 MAOB (0.61) SLC1A5MAOBMAOAALDH1A1CHEK1
SCHEMBL16950715 0.77 ALDH1A1 (0.36) SLC1A5ALDH1A1
SCHEMBL6897410 0.77 ALDH1A1 (0.40) VCAM1SLC1A5ALDH1A1LMNAMAPK1
SCHEMBL31310581 0.76 MAOB (0.44) SLC1A5MAOBMAOACHEK1MCL1
SCHEMBL19062226 0.76 MAOB (0.44) SLC1A5MAOBMAOACHEK1MCL1
SCHEMBL1343188 0.76 MAOB (0.44) SLC1A5MAOBMAOAGRM4ALDH1A1
SCHEMBL104941 0.76 VCAM1 (0.52) VCAM1TRPV4MAOBMAOASLC22A12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113321577-A Preparation method of 5-bromo-2-chlorobenzoic acid 上海立科化学科技有限公司 2021-08-31 — — CN claimed
EP-4739669-A1 SODIUM CHANNEL BLOCKERS Novartis AG (CH) 2026-05-13 — — EP disclosed
US-20260124309-A1 STAT6 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2026-05-07 — — US disclosed
US-20260008757-A1 N-(3-(AMINOMETHYL)-PHENYL)-5-(4-PHENYL)-5-(TRIFLUOROMETHYL)-4,5-DIHYDROISOXAZOL-3-AMINE DERIVATIVES AND SIMILAR COMPOUNDS AS PESTICIDES BASF SE (DE) 2026-01-08 — — US disclosed
CN-120152959-A N- (3- (aminomethyl) -phenyl) -5- (4-phenyl) -5- (trifluoromethyl) -4, 5-dihydroisoxazol-3-amine derivatives and similar compounds as pesticides 巴斯夫欧洲公司 2025-06-13 — — CN disclosed
WO-2025049820-A1 STAT6 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2025-03-06 — — WO disclosed
US-20250034108-A1 SODIUM CHANNEL BLOCKERS NOVARTIS AG (CH) 2025-01-30 — — US disclosed
US-12209092-B2 Inhibitors of GLI1 as therapeutic agents NEW YORK UNIVERSITY (US) 2025-01-28 — — US disclosed
WO-2025011450-A1 SODIUM CHANNEL BLOCKERS NOVARTIS AG (CH) 2025-01-16 — — WO disclosed
EP-4065566-B1 TRPM8 MODULATORS GIVAUDAN SA (CH) 2025-01-01 — — EP disclosed
WO-2011094953-A1 COMPOUNDS FOR THE TREATMENT AND PREVENTION OF INFLUENZA F. HOFFMANN-LA ROCHE AG (CH) 2011-08-11 — — WO disclosed
US-20110028441-A1 NOVEL PHENYL-SUBSTITUTED PIPERAZINO-DIHYDROTHIENOPYRIMIDINES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-02-03 — — US disclosed
US-20110028441-A1 NOVEL PHENYL-SUBSTITUTED PIPERAZINO-DIHYDROTHIENOPYRIMIDINES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-02-03 — — US disclosed
US-20110028441-A1 NOVEL PHENYL-SUBSTITUTED PIPERAZINO-DIHYDROTHIENOPYRIMIDINES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-02-03 — — US disclosed
US-20100267676-A1 GAMMA-AMINO-BUTYRIC ACID DERIVATIVES AS GABAB RECEPTOR LIGANDS XENOPORT, INC. 2010-10-21 — — US disclosed
WO-2010120370-A2 GAMMA-AMINO-BUTYRIC ACID DERIVATIVES AS GABAB RECEPTOR LIGANDS XENOPORT, INC. (US) 2010-10-21 — — WO disclosed
EP-2214673-A1 NOVEL PHENYL-SUBSTITUTED PIPERAZINO-DIHYDROTHIENOPYRIMIDINES Boehringer Ingelheim International GmbH (DE) 2010-08-11 — — EP disclosed
WO-2009053268-A1 NOVEL PHENYL-SUBSTITUTED PIPERAZINO-DIHYDROTHIENOPYRIMIDINES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-04-30 — — WO disclosed
WO-2009053268-A1 NOVEL PHENYL-SUBSTITUTED PIPERAZINO-DIHYDROTHIENOPYRIMIDINES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-04-30 — — WO disclosed
US-3966728-A ANTIPEPTIC ULCER ACTIVITY NIPPON SHINYAKU CO., LTD. (JA) 1976-06-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12209092-B2 Inhibitors of GLI1 as therapeutic agents GLI1, GLI2, SHH VCAM1 2738/4885SLC1A5 3590/4885TRPV4 4739/4885
US-20260124309-A1 STAT6 DEGRADERS AND USES THEREOF STAT6, NCOR2, NCOR1 VCAM1 4487/4885SLC1A5 3265/4885TRPV4 2174/4885
US-20100267676-A1 GAMMA-AMINO-BUTYRIC ACID DERIVATIVES AS GABAB RECEPTOR LIGANDS GABRB2, GABRB1, GABRB3 VCAM1 3317/4885SLC1A5 131/4885TRPV4 1801/4885
US-20250034108-A1 SODIUM CHANNEL BLOCKERS SCN5A, SCN2B, SCN1B VCAM1 1217/4885SLC1A5 287/4885TRPV4 76/4885
US-20260008757-A1 N-(3-(AMINOMETHYL)-PHENYL)-5-(4-PHENYL)-5-(TRIFLUOROMETHYL)-4,5-DIHYDROISOXAZOL-3-AMINE DERIVATIVES AND SIMILAR COMPOUNDS AS PESTICIDES HCN1, HCN3, HTR3C VCAM1 3232/4885SLC1A5 1401/4885TRPV4 587/4885
US-20110028441-A1 NOVEL PHENYL-SUBSTITUTED PIPERAZINO-DIHYDROTHIENOPYRIMIDINES DPYD, DPM1, DDX41 VCAM1 2766/4885SLC1A5 1969/4885TRPV4 299/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.