Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.59 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.56 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.48 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4640294 | 0.84 | KEAP1 (0.56) | KEAP1PRMT6PPARDAKR1B1HPGD | |
| SCHEMBL5662919 | 0.82 | PRMT6 (0.58) | KEAP1PRMT6PSMB5ALDH1A1POLB | |
| SCHEMBL10242931 | 0.80 | PRMT6 (0.56) | KEAP1PRMT6PSMB5ALDH1A1POLB | |
| SCHEMBL9454526 | 0.80 | PRMT6 (0.63) | KEAP1PRMT6PSMB5ALDH1A1POLB | |
| SCHEMBL28032595 | 0.79 | LMNA (0.63) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL28267802 | 0.78 | PRMT6 (0.66) | KEAP1PRMT6PSMB5ALDH1A1HPGD | |
| SCHEMBL10242915 | 0.78 | PRMT6 (0.53) | KEAP1PRMT6PSMB5ALDH1A1POLB | |
| SCHEMBL4033591 | 0.77 | CYP4F2 (0.58) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL538397 | 0.77 | ABCC4 (0.67) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL1346211 | 0.77 | PRMT6 (0.59) | KEAP1PRMT6PSMB5ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471923-A4 | AMIDO MACROLIDES | KOSAN BIOSCIENCES INC (US) | 2006-01-11 | — | — | EP | disclosed |
| US-6939861-B2 | Amido macrolides | KOSAN BIOSCIENCES, INC. (US) | 2005-09-06 | — | — | US | disclosed |
| EP-1471923-A1 | AMIDO MACROLIDES | Kosan Biosciences, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| US-20030199458-A1 | Amido macrolides | KOSAN BIOSCIENCES, INC. | 2003-10-23 | — | — | US | disclosed |
| WO-2003061671-A1 | AMIDO MACROLIDES | KOSAN BIOSCIENCES, INC. (US) | 2003-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199458-A1 | Amido macrolides | PCSK9, ABCB4, PCSK7 | KEAP1 3123/4885PRMT6 3021/4885GRIN2D 4340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.