Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 4/20 | 0.34 |
| ▸ | CA2 known ✓ | P00918 | 4/20 | 0.34 |
| ▸ | NOD2 known ✓ | Q9HC29 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5702318 | 0.78 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2CA1CA2MEN1 | |
| Cyclopropane Carboxylic Acid SCHEMBL10978847 | 0.77 | ALDH1A1 (0.57) | ALDH1A1CA1CA2MEN1KMT2A | |
| Methyl Alcohol SCHEMBL7073942 | 0.74 | GAA (0.48) | ALDH1A1SMN1; SMN2CA1CA2MEN1 | |
| Chloramine-T Anhydrous SCHEMBL19335 | 0.74 | GAA (0.52) | ALDH1A1SMN1; SMN2CA1CA2MEN1 | |
| SCHEMBL2372301 | 0.74 | GAA (0.52) | ALDH1A1SMN1; SMN2CA1CA2MEN1 | |
| SCHEMBL8908023 | 0.74 | GAA (0.52) | ALDH1A1SMN1; SMN2CA1CA2MEN1 | |
| SCHEMBL31448661 | 0.74 | GAA (0.52) | ALDH1A1SMN1; SMN2CA1CA2MEN1 | |
| SCHEMBL2404507 | 0.74 | CA1 (0.38) | ALDH1A1SMN1; SMN2CA1CA2MEN1 | |
| SCHEMBL7098700 | 0.74 | ALDH1A1 (0.34) | ALDH1A1SMN1; SMN2CA1CA2MEN1 | |
| Timonacic SCHEMBL9846803 | 0.74 | KDM4E (0.39) | ALDH1A1SMN1; SMN2CA1CA2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915844-B1 | PROCESS FOR PREPARING 3-PYRROLINE-2-CARBOXYLIC ACID DERIVATIVES | ABBOTT GMBH & CO KG (DE) | 2006-04-26 | — | — | EP | claimed |
| EP-0915844-A1 | PROCESS FOR PREPARING 3-PYRROLINE-2-CARBOXYLIC ACID DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 1999-05-19 | — | — | EP | claimed |
| WO-1998004523-A1 | PROCESS FOR PREPARING 3-PYRROLINE-2-CARBOXYLIC ACID DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 1998-02-05 | — | — | WO | claimed |