Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 3/20 | 0.38 |
| ▸ | CA2 known ✓ | P00918 | 3/20 | 0.38 |
| ▸ | NOD2 known ✓ | Q9HC29 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.32 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5702318 | 0.85 | ALDH1A1 (0.40) | CA1CA2ALDH1A1MEN1KMT2A | |
| Cyclopropane Carboxylic Acid SCHEMBL10978847 | 0.79 | ALDH1A1 (0.57) | CA1CA2ALDH1A1MEN1KMT2A | |
| SCHEMBL7098700 | 0.76 | ALDH1A1 (0.34) | CA1CA2ALDH1A1MEN1KMT2A | |
| SCHEMBL4778393 | 0.75 | ALDH1A1 (0.43) | CA1CA2ALDH1A1MEN1KMT2A | |
| SCHEMBL4778394 | 0.75 | ALDH1A1 (0.43) | CA1CA2ALDH1A1MEN1KMT2A | |
| SCHEMBL7046780 | 0.74 | HTR6 (0.38) | ALDH1A1MEN1KMT2ATSHRPOLB | |
| Trichloroacetic Acid SCHEMBL7739321 | 0.74 | ALDH1A1 (0.41) | CA1CA2ALDH1A1MEN1KMT2A | |
| SCHEMBL5691690 | 0.74 | EGLN1 (0.50) | CA1CA2ALDH1A1MEN1KMT2A | |
| SCHEMBL4726308 | 0.73 | RAB9A (0.37) | CA1CA2ALDH1A1MEN1KMT2A | |
| Methyl Alcohol SCHEMBL7073942 | 0.73 | GAA (0.48) | CA1CA2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295573-A1 | ENGINEERED NEOCARTILAGE TISSUE COMPOSITIONS | UNIV CALIFORNIA (US) | 2023-09-21 | — | — | US | disclosed |
| US-11696929-B2 | Methods and systems for conserving highly expanded cells | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2023-07-11 | — | — | US | disclosed |
| US-20220025331-A1 | METHODS AND SYSTEMS FOR IMPROVING CELLS FOR USE IN THERAPY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-01-27 | — | — | US | disclosed |
| US-20190085292-A1 | METHODS AND SYSTEMS FOR IMPROVING CELLS FOR USE IN THERAPY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-03-21 | — | — | US | disclosed |
| US-20190083544-A1 | METHODS AND SYSTEMS FOR CONSERVING HIGHLY EXPANDED CELLS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-03-21 | — | — | US | disclosed |
| WO-2014065863-A1 | COMPOSITIONS AND METHODS FOR PROMOTING COLLAGEN-CROSSLINKING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-05-01 | — | — | WO | disclosed |
| US-20110212894-A1 | DECELLULARIZATION METHOD FOR SCAFFOLDLESS TISSUE ENGINEERED ARTICULAR CARTILAGE OR NATIVE CARTILAGE TISSUE | ATHANASIOU KYRIACOS A | 2011-09-01 | — | — | US | disclosed |
| WO-2010022074-A1 | A DECELLULARIZATION METHOD FOR SCAFFOLDLESS TISSUE ENGINEERED ARTICULAR CARTILAGE OR NATIVE CARTILAGE TISSUE | WILLIAM MARSH RICE UNIVERSITY (US) | 2010-02-25 | — | — | WO | disclosed |
| US-20090142307-A1 | Shape-Based Approach for Scaffoldless Tissue Engineering | NATIONAL INSTITUTES OF HEALTH | 2009-06-04 | — | — | US | disclosed |
| EP-2007312-A2 | A SHAPE-BASED APPROACH FOR SCAFFOLDLESS TISSUE ENGINEERING | William Marsh Rice University (US) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007115336-A2 | A SHAPE-BASED APPROACH FOR SCAFFOLDLESS TISSUE ENGINEERING | WILLIAM MARSH RICE UNIVERSITY (US) | 2007-10-11 | — | — | WO | disclosed |