Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GPR3 | P46089 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 7/20 | 0.35 |
| ▸ | GABRD | O14764 | 7/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 7/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 7/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6239562 | 0.86 | MAOA (0.43) | HSD17B10PARP1ALDH1A1GABRA1GABRG2 | |
| SCHEMBL5759399 | 0.82 | MEN1 (0.35) | HSD17B10PARP1KMT2AMEN1NPC1 | |
| SCHEMBL5757920 | 0.81 | SIGMAR1 (0.37) | HSD17B10KMT2AMEN1NPC1RAB9A | |
| SCHEMBL5756740 | 0.81 | GABRA1 (0.39) | HSD17B10PARP1KMT2AMEN1NPC1 | |
| SCHEMBL5759048 | 0.77 | TSHR (0.40) | HSD17B10KMT2AMEN1ALDH1A1GPR3 | |
| SCHEMBL6897737 | 0.74 | ALDH1A1 (0.45) | HSD17B10KMT2AMEN1ALDH1A1GPR3 | |
| SCHEMBL328963 | 0.72 | ALDH1A1 (0.41) | HSD17B10PARP1KMT2AMEN1NPC1 | |
| SCHEMBL11143149 | 0.70 | LRRK2 (0.43) | HSD17B10PARP1KMT2AMEN1NPC1 | |
| SCHEMBL5757538 | 0.66 | GABRP (0.33) | HSD17B10PARP1KMT2AMEN1NPC1 | |
| SCHEMBL8743645 | 0.66 | MTOR (0.41) | HSD17B10PARP1KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104403-B1 | HYDROXY PIPECOLATE HYDROXAMIC ACID DERIVATIVES AS MMP INHIBITORS | PFIZER PROD INC (US) | 2006-05-10 | — | — | EP | disclosed |
| US-20050215549-A1 | TACE inhibitors | MCCLURE KIM F | 2005-09-29 | — | — | US | disclosed |
| EP-1104412-B1 | TACE INHIBITORS | PFIZER PROD INC (US) | 2005-06-15 | — | — | EP | disclosed |
| US-20030181441-A1 | TACE INHIBITORS | McCLURE Kim (US) | 2003-09-25 | — | — | US | disclosed |
| US-6329397-B1 | TREATMENT OF A CONDITION SELECTED FROM THE GROUP CONSISTING OF ARTHRITIS, CANCER, AND OTHER DISEASES CHARACTERIZED BY MATRIX METALLOPROTEINASE OR MAMMALIAN REPROLYSIN ACTIVITY. | PFIZER | 2001-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181441-A1 | TACE INHIBITORS | ADAMTS5, ADAMTS1, MMP2 | HSD17B10 2714/4885PARP1 149/4885KMT2A 2819/4885 |
| US-20050215549-A1 | TACE inhibitors | ADAMTS5, ADAMTS1, MMP2 | HSD17B10 2276/4885PARP1 291/4885KMT2A 2682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.