Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.47 |
| ▸ | PTGES2 | Q9H7Z7 | 5/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
| ▸ | CCR4 | P51679 | 1/20 | 0.39 |
| ▸ | DUSP5 | Q16690 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680068 | 0.83 | MCOLN3 (0.41) | TSHRMCOLN3PTGES2AKR1B1PGR | |
| SCHEMBL1421724 | 0.82 | HSD11B1 (0.48) | TSHRAKR1B1PGRLMNAALDH1A1 | |
| SCHEMBL439048 | 0.80 | HTT (0.41) | TSHRLMNAALDH1A1TDP1 | |
| SCHEMBL29396421 | 0.80 | HTT (0.41) | TSHRLMNAALDH1A1TDP1 | |
| SCHEMBL1248188 | 0.79 | AKR1B1 (0.56) | TSHRMCOLN3PTGES2AKR1B1KMT2A | |
| SCHEMBL6908682 | 0.79 | HSD11B1 (0.50) | TSHRAKR1B1PGRLMNAALDH1A1 | |
| Potassium Ion SCHEMBL3190633 | 0.78 | HTT (0.40) | TSHRLMNAALDH1A1TDP1 | |
| SCHEMBL31346644 | 0.78 | MAPT (0.56) | TSHRKMT2ASLC40A1DUSP5MEN1 | |
| SCHEMBL5607122 | 0.77 | TSHR (0.53) | TSHRMCOLN3PTGES2AKR1B1KMT2A | |
| SCHEMBL6912706 | 0.77 | HSD11B1 (0.48) | TSHRAKR1B1PGRLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3365168-B1 | LIGHTWEIGHT FLAME RETARDANT THERMOPLASTIC STRUCTURES | SCHNELLER LLC (US) | 2021-06-30 | — | — | EP | claimed |
| CN-108367529-B | Lightweight flame retardant thermoplastic structures | 施内勒公司 | 2021-02-05 | — | — | CN | claimed |
| EP-3365168-A1 | LIGHTWEIGHT FLAME RETARDANT THERMOPLASTIC STRUCTURES | Schneller, LLC (US) | 2018-08-29 | — | — | EP | claimed |
| WO-2017070276-A1 | LIGHTWEIGHT FLAME RETARDANT THERMOPLASTIC STRUCTURES | SCHNELLER LLC (US) | 2017-04-27 | — | — | WO | claimed |
| US-20170113445-A1 | LIGHTWEIGHT FLAME RETARDANT THERMOPLASTIC STRUCTURES | SCHNELLER LLC | 2017-04-27 | — | — | US | claimed |
| US-8975367-B2 | Polyphosphonate and copolyphosphonate additive mixtures | FRX POLYMERS, INC. (US) | 2015-03-10 | — | — | US | claimed |
| JP-62257964-A | — | — | None | — | — | JP | disclosed |
| EP-3365168-B1 | LIGHTWEIGHT FLAME RETARDANT THERMOPLASTIC STRUCTURES | SCHNELLER LLC (US) | 2021-06-30 | — | — | EP | disclosed |
| CN-108367529-B | Lightweight flame retardant thermoplastic structures | 施内勒公司 | 2021-02-05 | — | — | CN | disclosed |
| US-20200338873-A1 | LIGHTWEIGHT FLAME RETARDANT THERMOPLASTIC STRUCTURES | SCHNELLER LLC (US) | 2020-10-29 | — | — | US | disclosed |
| CN-109971144-A | Polyphosphonates and copolymerization phosphonate additives mixture | FRX 聚合物股份有限公司 | 2019-07-05 | — | — | CN | disclosed |
| EP-3365168-A1 | LIGHTWEIGHT FLAME RETARDANT THERMOPLASTIC STRUCTURES | Schneller, LLC (US) | 2018-08-29 | — | — | EP | disclosed |
| EP-1951815-B1 | FLAME RESISTANT POLYMER BLENDS | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2017-05-24 | — | — | EP | disclosed |
| US-20070065615-A1 | ANNULAR OR TUBULAR SHAPED ARTICLES OF NOVEL POLYMER BLENDS | CITIBANK, N.A., AS COLLATERAL AGENT | 2007-03-22 | — | — | US | disclosed |
| US-20070066740-A1 | Annular or tubular shaped articles of novel polymer blends | CITIBANK, N.A., AS COLLATERAL AGENT | 2007-03-22 | — | — | US | disclosed |
| EP-1731568-A1 | ORGANOPOLYSILOXANE-CONTAINING GRAFT COPOLYMER COMPOSITION | Kaneka Corporation (JP) | 2006-12-13 | — | — | EP | disclosed |
| EP-0194578-B1 | PROTEINS IMMOBILISED ON POLYAMIDES OR CELLULOSE HYDRATE AND THE USE THEREOF FOR THE PREPARATION OF BIOCATALYSTS, TEST STRIPS OR CHROMATOGRAPHY MATERIALS | MILES INC. (US) | 1992-12-09 | — | — | EP | disclosed |
| US-4808529-A | IMPREGNATING A MEMBRANE CARRIER WITH PROTEIN SOLUTION | MILES INC. (US) | 1989-02-28 | — | — | US | disclosed |
| JP-S62257964-A | POLYESTER IMIDE COMPOSITION | TEIJIN LTD | 1987-11-10 | — | — | JP | disclosed |
| EP-0194578-A2 | Proteins immobilised on polyamides or cellulose hydrate and the use thereof for the preparation of biocatalysts, test strips or chromatography materials | MILES INC. (US) | 1986-09-17 | — | — | EP | disclosed |