Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY4 known ✓ | P51582 | 2/20 | 0.41 |
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.38 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.38 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.36 |
| ▸ | P2RY2 known ✓ | P41231 | 1/20 | 0.36 |
| ▸ | P2RY12 known ✓ | Q9H244 | 1/20 | 0.36 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.41 |
| ▸ | PKLR | P30613 | 3/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.40 |
| ▸ | PGAM1 | P18669 | 2/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11473674 | 0.88 | PKLR (0.39) | MCOLN3P2RY4PKLRPTGES2TSHR | |
| SCHEMBL583980 | 0.83 | TSHR (0.50) | MCOLN3PTGES2TSHRPGRHSD11B1 | |
| SCHEMBL29910306 | 0.82 | PKLR (0.52) | P2RY4PKLRPTPN1PGAM1P2RY2 | |
| SCHEMBL4274718 | 0.82 | PKLR (0.52) | P2RY4PKLRPTPN1PGAM1P2RY2 | |
| SCHEMBL11775615 | 0.80 | MCOLN3 (0.42) | MCOLN3PTGES2TSHRCA1CA2 | |
| SCHEMBL1421724 | 0.78 | HSD11B1 (0.48) | P2RY4PKLRTSHRPGRHSD11B1 | |
| SCHEMBL6908682 | 0.76 | HSD11B1 (0.50) | TSHRPGRHSD11B1AKR1B1 | |
| SCHEMBL29213550 | 0.75 | PKLR (0.46) | PKLRPTPN1CA1CA2PGAM1 | |
| SCHEMBL6913303 | 0.74 | HSD11B1 (0.48) | TSHRPGRHSD11B1AKR1B1 | |
| SCHEMBL6913965 | 0.74 | HSD11B1 (0.48) | TSHRPGRHSD11B1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2294139-B1 | POLYSILOXANE-POLYCARBONATE COMPOSITIONS, METHOD OF MANUFACTURE, AND ARTICLES FORMED THEREFROM | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2017-12-27 | — | — | EP | disclosed |
| EP-2238196-B1 | FLAME RETARDANT POLYIMIDE/POLYESTER-POLYCARBONATE COMPOSITIONS, METHODS OF MANUFACTURE, AND ARTICLES FORMED THEREFROM | SABIC INNOVATIVE PLASTICS IP (NL) | 2013-12-18 | — | — | EP | disclosed |
| US-8389648-B2 | Polysiloxane-polycarbonate compositions, method of manufacture, and articles formed therefrom | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2013-03-05 | — | — | US | disclosed |
| US-20110288214-A1 | POLYSILOXANE-POLYCARBONATE COMPOSITIONS, METHOD OF MANUFACTURE, AND ARTICLES FORMED THEREFROM | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2011-11-24 | — | — | US | disclosed |
| US-7994254-B2 | Polysiloxane-polycarbonate compositions, and related methods and articles | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2011-08-09 | — | — | US | disclosed |
| EP-2294139-A1 | POLYSILOXANE-POLYCARBONATE COMPOSITIONS, METHOD OF MANUFACTURE, AND ARTICLES FORMED THEREFROM | SABIC Innovative Plastics IP B.V. (NL) | 2011-03-16 | — | — | EP | disclosed |
| EP-2238196-A2 | FLAME RETARDANT POLYIMIDE/POLYESTER-POLYCARBONATE COMPOSITIONS, METHODS OF MANUFACTURE, AND ARTICLES FORMED THEREFROM | SABIC Innovative Plastics IP B.V. (NL) | 2010-10-13 | — | — | EP | disclosed |
| US-7732516-B2 | Flame retardant polyimide/polyester-polycarbonate compositions, methods of manufacture, and articles formed therefrom | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2010-06-08 | — | — | US | disclosed |
| US-20090318629-A1 | POLYSILOXANE-POLYCARBONATE COMPOSITIONS, AND RELATED METHODS AND ARTICLES | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2009-12-24 | — | — | US | disclosed |
| WO-2009155013-A1 | POLYSILOXANE-POLYCARBONATE COMPOSITIONS, METHOD OF MANUFACTURE, AND ARTICLES FORMED THEREFROM | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2009-12-23 | — | — | WO | disclosed |
| WO-2009095825-A2 | FLAME RETARDANT POLYIMIDE/POLYESTER-POLYCARBONATE COMPOSITIONS, METHODS OF MANUFACTURE, AND ARTICLES FORMED THEREFROM | SABIC INNOVATIVE PLASTICS IP B.V. (US) | 2009-08-06 | — | — | WO | disclosed |
| US-20090197999-A1 | Flame Retardant Polyimide/Polyester-Polycarbonate Compositions, Methods of Manufacture, and Articles Formed Therefrom | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2009-08-06 | — | — | US | disclosed |