Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.63 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.60 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.60 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.60 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | PPIA | P62937 | 3/20 | 0.50 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | LIPE | Q05469 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19034905 | 0.85 | TDP1 (0.61) | BRD4PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL5516797 | 0.85 | L3MBTL1 (0.56) | BRD4PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL4281333 | 0.82 | BRD4 (0.65) | BRD4PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL5297530 | 0.82 | L3MBTL1 (0.62) | TDP1L3MBTL1NPC1GAATHRB | |
| SCHEMBL3619403 | 0.80 | BRD4 (0.77) | BRD4TDP1L3MBTL1PPIASGMS2 | |
| SCHEMBL8113906 | 0.80 | MRGPRX4 (0.50) | BRD4PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL4297414 | 0.79 | BRD4 (0.74) | BRD4TDP1L3MBTL1PPIASGMS2 | |
| SCHEMBL3927268 | 0.79 | CYP19A1 (0.48) | BRD4PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL9461095 | 0.78 | BRD4 (0.59) | BRD4TDP1L3MBTL1PPIASGMS2 | |
| SCHEMBL29557428 | 0.78 | POLB (0.56) | NPC1GAAMAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109243-B2 | Inhibitors of cathepsin S | IRM LLC (BM) | 2006-09-19 | — | — | US | disclosed |
| WO-2004084842-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2004-10-07 | — | — | WO | disclosed |
| US-20040198780-A1 | Inhibitors of cathepsin S | IRM LLC (BM) | 2004-10-07 | — | — | US | disclosed |
| US-6620823-B2 | Antiinflammatory agents; rheumatic disorders | BRISTOL-MYERS SQUIBB PHARME COMPANY | 2003-09-16 | — | — | US | disclosed |
| EP-1299379-A2 | LACTAM METALLOPROTEASE INHIBITORS | Bristol-Myers Squibb Pharma Company (US) | 2003-04-09 | — | — | EP | disclosed |
| US-20020042398-A1 | Novel lactam metalloprotease inhibitors | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-04-11 | — | — | US | disclosed |
| WO-2002004416-A2 | LACTAM METALLOPROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2002-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020042398-A1 | Novel lactam metalloprotease inhibitors | ADAM9, ADAM8, ADAM17 | BRD4 1453/4885PTGER1 1250/4885PTGER4 2797/4885 |
| US-20040198780-A1 | Inhibitors of cathepsin S | CTSS, CTSK, CTSE | BRD4 2378/4885PTGER1 2534/4885PTGER4 3862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.