Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ARHGDIA | P52565 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5833003 | 0.85 | SIGMAR1 (0.41) | LMNAKMT2AALDH1A1ACHEPOLB | |
| SCHEMBL5844908 | 0.81 | LMNA (0.36) | LMNAMAPTTP53KMT2AALDH1A1 | |
| SCHEMBL5833539 | 0.81 | CHRM2 (0.47) | MAPTSIGMAR1CHRM2CHRM3ROCK2 | |
| SCHEMBL5833452 | 0.78 | DCUN1D1 (0.40) | KMT2AMEN1ACHESIGMAR1UBE2M | |
| SCHEMBL5833112 | 0.78 | ROCK2 (0.41) | ACHECHRM2CHRM3FAAHROCK2 | |
| SCHEMBL5833937 | 0.77 | OPRD1 (0.47) | KMT2AACHEHTTCHRM2CHRM3 | |
| SCHEMBL5833278 | 0.77 | RNF4 (0.42) | ACHECHRM2CHRM3FAAH | |
| SCHEMBL5833269 | 0.77 | KDM1A (0.40) | KMT2AMEN1FAAHMCHR1DCUN1D1 | |
| SCHEMBL5833430 | 0.75 | SIGMAR1 (0.43) | KMT2AMEN1ACHEPOLBSIGMAR1 | |
| SCHEMBL5833024 | 0.74 | BRD4 (0.38) | KMT2AMEN1SIGMAR1CHRM2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7008955-B2 | (2-azabicyclo[2.2.1]hept-7yl) methanol derivatives as nicotinic acetylcholine receptor agonists | MERCK PATENT GMBH (DE) | 2006-03-07 | — | — | US | claimed |