Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5844904 | 0.85 | LMNA (0.38) | SIGMAR1HTTMCHR1POLBKMT2A | |
| SCHEMBL5833024 | 0.79 | BRD4 (0.38) | SIGMAR1BRD4KMT2ACHRM2CHRM3 | |
| SCHEMBL5833006 | 0.79 | HTT (0.38) | SIGMAR1MAPK1HTTARPOLB | |
| SCHEMBL5833539 | 0.77 | CHRM2 (0.47) | SIGMAR1BRD4CHRM2CHRM3 | |
| SCHEMBL5833278 | 0.77 | RNF4 (0.42) | CHRM2CHRM3ACHE | |
| SCHEMBL5833112 | 0.76 | ROCK2 (0.41) | BRD4CHRM2CHRM3ACHE | |
| SCHEMBL5833530 | 0.75 | MAPK1 (0.44) | SIGMAR1MAPK1KMT2AALDH1A1 | |
| SCHEMBL5833452 | 0.75 | DCUN1D1 (0.40) | SIGMAR1KMT2AACHE | |
| SCHEMBL5833937 | 0.74 | OPRD1 (0.47) | HTTBRD4KMT2ACHRM2CHRM3 | |
| SCHEMBL5833430 | 0.73 | SIGMAR1 (0.43) | SIGMAR1POLBKMT2ACHRM2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7008955-B2 | (2-azabicyclo[2.2.1]hept-7yl) methanol derivatives as nicotinic acetylcholine receptor agonists | MERCK PATENT GMBH (DE) | 2006-03-07 | — | — | US | claimed |