Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | AOC3 | Q16853 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13507144 | 0.81 | KDM4E (0.60) | LMNAKDM4EL3MBTL1RIPK1AOC3 | |
| SCHEMBL4817914 | 0.81 | LMNA (0.47) | LMNAKDM4EL3MBTL1RIPK1AOC3 | |
| SCHEMBL31489960 | 0.80 | AOC3 (0.48) | KDM4EAOC3GAA | |
| SCHEMBL16861908 | 0.80 | RIPK1 (0.68) | LMNAKDM4EL3MBTL1RIPK1AOC3 | |
| SCHEMBL12847277 | 0.80 | RIPK1 (0.68) | LMNAKDM4EL3MBTL1RIPK1AOC3 | |
| SCHEMBL10414449 | 0.79 | LMNA (0.45) | LMNAKDM4EL3MBTL1RIPK1AOC3 | |
| SCHEMBL24015547 | 0.78 | ALDH1A1 (0.40) | LMNAKDM4EAOC3 | |
| SCHEMBL5609128 | 0.78 | RIPK1 (0.60) | LMNAKDM4EL3MBTL1RIPK1AOC3 | |
| SCHEMBL20644495 | 0.78 | PTPN5 (0.40) | LMNAKDM4EAOC3MEN1KMT2A | |
| SCHEMBL18285644 | 0.78 | HSD11B1 (0.50) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105017245-B | Imidazopyridine compound and preparation method and application thereof | 华东师范大学 | 2017-01-18 | — | — | CN | claimed |
| US-12435078-B2 | Pyridazinones and methods of use thereof | GFB (ABC), LLC (US) | 2025-10-07 | — | — | US | disclosed |
| US-20230203028-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | GFB (ABC), LLC | 2023-06-29 | — | — | US | disclosed |
| US-20230203028-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | GFB (ABC), LLC | 2023-06-29 | — | — | US | disclosed |
| US-20230203028-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | GFB (ABC), LLC | 2023-06-29 | — | — | US | disclosed |
| US-20230086702-A1 | SUBSTITUTED 2-AMINO-PYRAZOLYL-[1,2,4]TRIAZOLO[1,5A]PYRIDINE DERIVATIVES AND USE THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 2023-03-23 | — | — | US | disclosed |
| EP-3956330-A1 | SUBSTITUTED 2-AMINO-PYRAZOLYL-[1,2,4]TRIAZOLO[1,5A] PYRIDINE DERIVATIVES AND USE THEREOF | The Johns Hopkins University (US) | 2022-02-23 | — | — | EP | disclosed |
| WO-2020215094-A1 | SUBSTITUTED 2-AMINO-PYRAZOLYL-[1,2,4]TRIAZOLO[1,5A] PYRIDINE DERIVATIVES AND USE THEREOF | THE JOHNS HOPKINS UNIVERSITY (US) | 2020-10-22 | — | — | WO | disclosed |
| EP-3684364-A2 | PYRIDAZINONES AND METHODS OF USE THEREOF | Goldfinch Bio, Inc. (US) | 2020-07-29 | — | — | EP | disclosed |
| CN-108440384-B | Process for the preparation of trifluoromethylated derivatives of isoindolones | 苏州大学 | 2020-04-10 | — | — | CN | disclosed |
| WO-2019055966-A2 | PYRIDAZINONES AND METHODS OF USE THEREOF | GOLDFINCH BIO, INC. (US) | 2019-03-21 | — | — | WO | disclosed |
| CN-108440384-A | The preparation method of the trifluoromethyl hydroxylation derivative of isoindolone | 苏州大学 | 2018-08-24 | — | — | CN | disclosed |
| CN-105017245-B | Imidazopyridine compound and preparation method and application thereof | 华东师范大学 | 2017-01-18 | — | — | CN | disclosed |
| US-7087789-B2 | Methods for nucleophilic fluoromethylation | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2006-08-08 | — | — | US | disclosed |
| US-20040230079-A1 | Methods for nucleophilic fluoromethylation | SOUTHERN CALIFORNIA, UNIVERSITY OF | 2004-11-18 | — | — | US | disclosed |
| WO-2004094353-A1 | PROCESS FOR THE MANUFACTURE OF 3,5-BIS(TRIFLUOROMETHYL)PHENYL-1-HYDROXYETHANE AND DERIVATIVE THEREOF | MITENI S.P.A. (IT) | 2004-11-04 | — | — | WO | disclosed |
| WO-2004063129-A2 | METHODS FOR NUCLEOPHILIC FLUOROMETHYLATION | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2004-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203028-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | PDXK, ATP6V1B1, REN | LMNA 715/4885KDM4E 3899/4885L3MBTL1 4848/4885 |
| US-20040230079-A1 | Methods for nucleophilic fluoromethylation | PHF2, HAO2, GSTM2 | LMNA 4803/4885KDM4E 2596/4885L3MBTL1 3004/4885 |
| US-12435078-B2 | Pyridazinones and methods of use thereof | PDXK, ATP6V1B1, REN | LMNA 715/4885KDM4E 3899/4885L3MBTL1 4848/4885 |
| US-20230086702-A1 | SUBSTITUTED 2-AMINO-PYRAZOLYL-[1,2,4]TRIAZOLO[1,5A]PYRIDINE DERIVATIVES AND USE THEREOF | SNCA, PSEN2, PRNP | LMNA 1793/4885KDM4E 2237/4885L3MBTL1 2687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.