Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.35 |
| ▸ | PGR | P06401 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.35 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.34 |
| ▸ | RELA | Q04206 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5887535 | 0.91 | MAPT (0.46) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL9834726 | 0.76 | ALDH1A1 (0.62) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL4746052 | 0.75 | THRB (0.35) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL6413864 | 0.74 | CA1 (0.39) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL9827142 | 0.73 | ALDH1A1 (0.62) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL14472966 | 0.71 | CA1 (0.50) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL8520613 | 0.70 | ALDH1A1 (0.62) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL9827152 | 0.70 | LMNA (0.43) | GAAPAOXLMNA | |
| SCHEMBL3687291 | 0.69 | L3MBTL1 (0.61) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL4746858 | 0.69 | FABP4 (0.68) | CA1CA2MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6982351-B2 | Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor | CELLGATE, INC. (US) | 2006-01-03 | — | — | US | disclosed |
| EP-1453787-A1 | CYCLOALKYL SUBSTITUTED POLYAMINES FOR CANCER THERAPY AND METHODS OF SYNTHESIS THEREFOR | SLIL Biomedical Corporation (US) | 2004-09-08 | — | — | EP | disclosed |
| US-20030195377-A1 | Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor | SLIL BIOMEDICAL CORPORATION | 2003-10-16 | — | — | US | disclosed |
| WO-2003050072-A1 | CYCLOALKYL SUBSTITUTED POLYAMINES FOR CANCER THERAPY AND METHODS OF SYNTHESIS THEREFOR | SLIL BIOMEDICAL CORPORATION (US) | 2003-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195377-A1 | Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor | PAICS, DHPS, DHFR | CA1 2456/4885CA2 3641/4885MMP1 3282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.