SCHEMBL5963736

SCHEMBL5963736

C=Cc1cccc(C(F)(F)F)c1F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFKB1 P19838 1/20 0.39
MPL P40238 3/20 0.37
GRIN2D O15399 2/20 0.36
GRIN3B O60391 2/20 0.36
GRIN1 Q05586 2/20 0.36
GRIN2A Q12879 2/20 0.36
GRIN2B Q13224 2/20 0.36
GRIN2C Q14957 2/20 0.36
GRIN3A Q8TCU5 2/20 0.36
IDO1 P14902 1/20 0.36
TDO2 P48775 1/20 0.36
ALDH1A1 P00352 1/20 0.35
AXL P30530 1/20 0.35
TNF P01375 1/20 0.35
IL6 P05231 1/20 0.35
HCAR1 Q9BXC0 1/20 0.35
MAOB P27338 3/20 0.34
CTSS P25774 1/20 0.34
NPC1 O15118 1/20 0.33
MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14197541 0.84 ALDH1A1 (0.33) NFKB1ALDH1A1
SCHEMBL25665109 0.82 ALOX12 (0.41) ALDH1A1
SCHEMBL21384829 0.81 PDE2A (0.35)
SCHEMBL29446986 0.80 NFKB1 (0.52) NFKB1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL165004 0.80 NFKB1 (0.52) NFKB1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL2094177 0.80 NFKB1 (0.41) NFKB1MPLGRIN2DGRIN3BGRIN1
SCHEMBL2094179 0.80 NFKB1 (0.41) NFKB1MPLGRIN2DGRIN3BGRIN1
SCHEMBL30991155 0.80 NFKB1 (0.31) NFKB1ALDH1A1
SCHEMBL574172 0.79 ALDH1A1 (0.46) ALDH1A1NFE2L2
SCHEMBL453534 0.79 NFKB1 (0.39) NFKB1GRIN2DGRIN3BGRIN1GRIN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11820844-B2 Charge-modified particles and methods of making the same 3M INNOVATIVE PROPERTIES COMPANY (US) 2023-11-21 US disclosed
CN-111886316-B Charge-modified particles and methods of making the same 3M创新有限公司 2021-07-09 CN disclosed
EP-3768794-B1 CHARGE-MODIFIED PARTICLES AND METHODS OF MAKING THE SAME 3M INNOVATIVE PROPERTIES CO (US) 2021-04-28 EP disclosed
EP-3768794-A2 CHARGE-MODIFIED PARTICLES AND METHODS OF MAKING THE SAME 3M Innovative Properties Company (US) 2021-01-27 EP disclosed
EP-3768655-A1 MODIFIED ALUMINUM NITRIDE PARTICLES AND METHODS OF MAKING THE SAME 3M Innovative Properties Company (US) 2021-01-27 EP disclosed
US-20210009811-A1 MODIFIED ALUMINUM NITRIDE PARTICLES AND METHODS OF MAKING THE SAME 3M INNOVATIVE PROPERTIES COMPANY 2021-01-14 US disclosed
US-20210002137-A1 CHARGE-MODIFIED PARTICLES AND METHODS OF MAKING THE SAME 3M INNOVATIVE PROPERTIES COMPANY 2021-01-07 US disclosed
CN-111886216-A Modified aluminum nitride particles and method for preparing same 3M创新有限公司 2020-11-03 CN disclosed
CN-111886316-A Charge-modified particles and methods of making the same 3M创新有限公司 2020-11-03 CN disclosed
CN-104749884-B Photosensitive polymer combination 东京应化工业株式会社 2019-10-18 CN disclosed
CN-103430098-A Positive-working lithographic printing plate precursor and method for preparing same EASTMAN KODAK CO 2013-12-04 CN disclosed
CN-103415808-A Lithographic printing plate precursor and method for producing lithographic printing plate FUJI PHOTO FILM CO LTD 2013-11-27 CN disclosed
CN-101781161-B Method for preparing trifluoromethyl styrene compound SHANGHAI CHEMEXPLORER CO LTD 2013-11-27 CN disclosed
US-7531533-B2 6-Membered heterocyclic compound and use thereof ASAHI KASEI PHARMA CORPORATION (JP) 2009-05-12 US disclosed
US-7429595-B2 Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents AVENTIS PHARMACEUTICALS INC. (US) 2008-09-30 US disclosed
US-20070060590-A1 6-Membered heterocyclic compound and use thereof ASAHI KASEI PHARMA CORPORATION (JP) 2007-03-15 US disclosed
EP-1634898-A2 Polymer having polymerizable group, polymerizable composition, planographic printing plate precursor, and planographic printing method using the same FUJI PHOTO FILM CO., LTD. (JP) 2006-03-15 EP disclosed
EP-0348906-B1 HEAT-RESISTANT RESIN COMPOSITION SHOWA DENKO KABUSHIKI KAISHA (JP) 1992-10-07 EP disclosed
US-4994515-A Resin of styrene and unsaturated imide, high impact thermoplastic, bromine-containing reaction product, silicon resin or compound SHOWA DENKO KABUSHIKI KAISHA (JP) 1991-02-19 US disclosed
EP-0348906-A1 Heat-resistant resin composition SHOWA DENKO KABUSHIKI KAISHA (JP) 1990-01-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070060590-A1 6-Membered heterocyclic compound and use thereof WNT1, CYP11B2, CYP11B1 NFKB1 2298/4885MPL 3851/4885GRIN2D 3425/4885
US-20210002137-A1 CHARGE-MODIFIED PARTICLES AND METHODS OF MAKING THE SAME PCTP, MBOAT1, CA13 NFKB1 3491/4885MPL 4060/4885GRIN2D 797/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.