Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 3/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.39 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10312521 | 0.86 | RAB9A (0.46) | NPC1RAB9AMAPTSMN1; SMN2HIF1A | |
| SCHEMBL16245851 | 0.83 | PKM (0.44) | NPC1RAB9AMAPTHPGDSMN1; SMN2 | |
| SCHEMBL3321542 | 0.83 | S1PR4 (0.52) | CYP2C9NPC1RAB9AKDM4EMAPT | |
| SCHEMBL1566534 | 0.83 | MAPK1 (0.54) | NPC1RAB9AMAPTHPGDSMN1; SMN2 | |
| SCHEMBL3326882 | 0.81 | MTOR (0.39) | RAB9AKDM4EMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL598575 | 0.81 | NPBWR1 (0.55) | NPC1RAB9AMAPTSMN1; SMN2HIF1A | |
| SCHEMBL6357575 | 0.76 | LMNA (0.44) | CYP2C9NPC1RAB9AMAPTHPGD | |
| SCHEMBL20653935 | 0.74 | OXTR (0.42) | MAPTSMN1; SMN2MAPK1NPBWR1MCHR1 | |
| SCHEMBL13225549 | 0.71 | HCAR2 (0.64) | HCAR2CYP2C8CYP2C9NPC1RAB9A | |
| SCHEMBL3327427 | 0.70 | ALDH1A1 (0.46) | CYP2C9KDM4ETP53SMN1; SMN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8115005-B2 | Pyrazolylphenyl and pyrrolylphenyl inhibitors of LTA4H for treating inflammation | DECODE GENETICS EHF. (IS) | 2012-02-14 | — | — | US | disclosed |
| US-8115005-B2 | Pyrazolylphenyl and pyrrolylphenyl inhibitors of LTA4H for treating inflammation | DECODE GENETICS EHF. (IS) | 2012-02-14 | — | — | US | disclosed |
| US-8115005-B2 | Pyrazolylphenyl and pyrrolylphenyl inhibitors of LTA4H for treating inflammation | DECODE GENETICS EHF. (IS) | 2012-02-14 | — | — | US | disclosed |
| WO-2008019302-A1 | PYRAZOLYLPHENYL AND PYRROLYLPHENYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2008-02-14 | — | — | WO | disclosed |
| WO-2008019302-A1 | PYRAZOLYLPHENYL AND PYRROLYLPHENYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2008-02-14 | — | — | WO | disclosed |
| US-20080033013-A1 | PYRAZOLYLPHENYL AND PYRROLYLPHENYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF. (IS) | 2008-02-07 | — | — | US | disclosed |
| US-20080033013-A1 | PYRAZOLYLPHENYL AND PYRROLYLPHENYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF. (IS) | 2008-02-07 | — | — | US | disclosed |
| US-20080033013-A1 | PYRAZOLYLPHENYL AND PYRROLYLPHENYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF. (IS) | 2008-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080033013-A1 | PYRAZOLYLPHENYL AND PYRROLYLPHENYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | LTB4R2, LTC4S, LTA4H | HCAR2 62/4885CYP2C8 168/4885CYP2C9 228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.