Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.40 |
| ▸ | AURKA | O14965 | 5/20 | 0.40 |
| ▸ | TEK | Q02763 | 5/20 | 0.40 |
| ▸ | LCK | P06239 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 5/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004207 | 0.85 | CYP1A2 (0.37) | KDRKDM4EGAAMEN1KMT2A | |
| SCHEMBL6004984 | 0.85 | PDE3B (0.39) | KDM4EGAAMETALDH1A1MAPT | |
| SCHEMBL6004710 | 0.80 | CYP3A4 (0.42) | KDRKDM4EMETALDH1A1NPC1 | |
| SCHEMBL6005438 | 0.80 | MET (0.35) | KDM4EMETALDH1A1MAPTNPC1 | |
| SCHEMBL6004082 | 0.79 | CBFB (0.37) | KDRKDM4EGAAMEN1KMT2A | |
| SCHEMBL6004857 | 0.78 | SRC (0.37) | KDRKDM4EGAAMEN1KMT2A | |
| SCHEMBL6004126 | 0.76 | ROCK2 (0.36) | KDRAURKATEKLCKMEN1 | |
| SCHEMBL6004067 | 0.75 | SLC22A12 (0.38) | KDRAURKATEKLCKMET | |
| SCHEMBL6003010 | 0.75 | PDE3B (0.41) | KDRAURKATEKLCKMEN1 | |
| SCHEMBL6005265 | 0.75 | TGFBR1 (0.44) | KDM4EMEN1KMT2AAURKBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |