Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016037 | 0.86 | HDAC6 (0.39) | HDAC1ALDH1A1LMNAKMT2AKDM4E | |
| SCHEMBL6016005 | 0.81 | L3MBTL1 (0.44) | ALDH1A1KMT2AKDM4EPOLBL3MBTL1 | |
| SCHEMBL6015656 | 0.79 | ALDH1A1 (0.39) | SMN1; SMN2HDAC1ALDH1A1LMNAKMT2A | |
| SCHEMBL6015645 | 0.79 | TERT (0.44) | LMNAKDM4EPOLB | |
| SCHEMBL27620069 | 0.73 | TSHR (0.37) | SMN1; SMN2ALDH1A1LMNAKMT2AKDM4E | |
| SCHEMBL6015865 | 0.71 | HPGD (0.38) | POLBHTR1AL3MBTL1 | |
| SCHEMBL6015654 | 0.68 | ALDH1A1 (0.33) | SMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL6352792 | 0.67 | KIF11 (0.41) | SMN1; SMN2ALDH1A1LMNAKDM4EHTR1A | |
| SCHEMBL12633984 | 0.66 | MMP12 (0.43) | SMN1; SMN2HDAC1KMT2APOLBSCN8A | |
| SCHEMBL7135231 | 0.66 | SMN1; SMN2 (0.51) | SMN1; SMN2HDAC1ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | claimed |
| EP-1181282-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | claimed |
| WO-2000075139-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-14 | — | — | WO | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |