Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7194392 | 0.77 | KEAP1 (0.57) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| SCHEMBL4250262 | 0.77 | PLCG1 (0.56) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| SCHEMBL3882288 | 0.77 | PSIP1 (0.50) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| SCHEMBL27498526 | 0.74 | KEAP1 (0.46) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| SCHEMBL8765877 | 0.74 | KEAP1 (0.46) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| SCHEMBL9703985 | 0.74 | KEAP1 (0.46) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| SCHEMBL385916 | 0.74 | KEAP1 (0.46) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| SCHEMBL11692985 | 0.74 | KEAP1 (0.46) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| SCHEMBL27519579 | 0.74 | KEAP1 (0.46) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| SCHEMBL3192160 | 0.74 | RAPGEF4 (0.39) | KEAP1NFE2L2ALDH1A1HTTRAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1089 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3986859-B1 | METHODS OF MAKING BEMPEDOIC ACID | ESPERION THERAPEUTICS INC (US) | 2025-04-30 | — | — | EP | claimed |
| US-20240317665-A1 | METHODS OF MAKING BEMPEDOIC ACID AND COMPOSITIONS OF THE SAME | CORDEN PHARMA COLORADO, INC. | 2024-09-26 | — | — | US | claimed |
| US-11987548-B2 | Methods of making bempedoic acid and compositions of the same | ESPERION THERAPEUTICS, INC. (US) | 2024-05-21 | — | — | US | claimed |
| US-20230183160-A1 | METHODS OF MAKING BEMPEDOIC ACID AND COMPOSITIONS OF THE SAME | GLAS AMERICAS LLC | 2023-06-15 | — | — | US | claimed |
| US-11407705-B2 | Methods of making bempedoic acid and compositions of the same | ESPERION THERAPEUTICS, INC. (US) | 2022-08-09 | — | — | US | claimed |
| EP-3986859-A1 | METHODS OF MAKING BEMPEDOIC ACID AND COMPOSITIONS OF THE SAME | Esperion Therapeutics, Inc. (US) | 2022-04-27 | — | — | EP | claimed |
| EP-3927685-A1 | A PROCESS FOR THE SYNTHESIS ANTHRANILIC DIAMIDE COMPOUNDS AND INTERMEDIATES THEREOF | PI Industries Ltd. (IN) | 2021-12-29 | — | — | EP | claimed |
| US-20210139401-A1 | METHODS OF MAKING BEMPEDOIC ACID AND COMPOSITIONS OF THE SAME | GLAS AMERICAS LLC | 2021-05-13 | — | — | US | claimed |
| WO-2020257571-A1 | METHODS OF MAKING BEMPEDOIC ACID AND COMPOSITIONS OF THE SAME | ESPERION THERAPEUTICS, INC. (US) | 2020-12-24 | — | — | WO | claimed |
| EP-3221335-A1 | SOLID PHASE SYNTHESIS OF CYCLIC AMINO ACID MOLECULES | Encycle Therapeutics (CA) | 2017-09-27 | — | — | EP | claimed |
| WO-2016079682-A1 | SOLID PHASE SYNTHESIS OF CYCLIC AMINO ACID MOLECULES | ENCYCLE THERAPEUTICS (CA) | 2016-05-26 | — | — | WO | claimed |
| US-9309253-B2 | Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2016-04-12 | — | — | US | claimed |
| US-20150141408-A1 | TRICYCLIC PYRROLO DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-05-21 | — | — | US | claimed |
| US-8975267-B2 | Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-03-10 | — | — | US | claimed |
| EP-2668190-A1 | TRICYCLIC PYRROLO DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2013-12-04 | — | — | EP | claimed |
| US-20130296305-A1 | TRICYCLIC PYRROLO DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-11-07 | — | — | US | claimed |
| WO-2012109735-A1 | METHODS OF PREPARING CYCLIC AMINO ACID MOLECULES USING ARYLBORONIC OR ARYLBORINIC ACID CATALYSTS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-08-23 | — | — | WO | claimed |
| WO-2012101032-A1 | TRICYCLIC PYRROLO DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-08-02 | — | — | WO | claimed |
| EP-2408802-A1 | CYCLIC AMINO ACID MOLECULES AND METHODS OF PREPARING THE SAME | The Governing Council of the University of Toronto (CA) | 2012-01-25 | — | — | EP | claimed |
| WO-2010105363-A1 | CYCLIC AMINO ACID MOLECULES AND METHODS OF PREPARING THE SAME | YUDIN ANDREI (CA) | 2010-09-23 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240317665-A1 | METHODS OF MAKING BEMPEDOIC ACID AND COMPOSITIONS OF THE SAME | ALOX5, ALOX15, CYP27A1 | KEAP1 2524/4885NFE2L2 1146/4885ALDH1A1 921/4885 |
| US-20230183160-A1 | METHODS OF MAKING BEMPEDOIC ACID AND COMPOSITIONS OF THE SAME | ALOX5, ALOX15, CYP27A1 | KEAP1 2524/4885NFE2L2 1146/4885ALDH1A1 921/4885 |
| US-11987548-B2 | Methods of making bempedoic acid and compositions of the same | ALOX5, ALOX15, CYP27A1 | KEAP1 2524/4885NFE2L2 1146/4885ALDH1A1 921/4885 |
| US-20150141408-A1 | TRICYCLIC PYRROLO DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | MAP3K1, MAP3K20, MAP3K6 | KEAP1 1162/4885NFE2L2 2908/4885ALDH1A1 4172/4885 |
| US-11407705-B2 | Methods of making bempedoic acid and compositions of the same | ALOX5, ALOX15, CYP27A1 | KEAP1 2524/4885NFE2L2 1146/4885ALDH1A1 921/4885 |
| US-20210139401-A1 | METHODS OF MAKING BEMPEDOIC ACID AND COMPOSITIONS OF THE SAME | ALOX5, ALOX15, CYP27A1 | KEAP1 2524/4885NFE2L2 1146/4885ALDH1A1 921/4885 |
| US-20130296305-A1 | TRICYCLIC PYRROLO DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | MAP3K1, MAP3K20, MAP3K5 | KEAP1 1189/4885NFE2L2 2508/4885ALDH1A1 3836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.