Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6065097 | 0.88 | PKM (0.45) | LMNAL3MBTL1CYP2C19ADORA3ADORA2A | |
| SCHEMBL6065771 | 0.86 | LMNA (0.35) | LMNAL3MBTL1CYP2C19RETKDR | |
| SCHEMBL6066190 | 0.85 | SMN1; SMN2 (0.35) | LMNAL3MBTL1CYP2C19RETKDR | |
| SCHEMBL6065740 | 0.81 | F2 (0.41) | LMNACYP2C19GAAALDH1A1HTT | |
| SCHEMBL6558343 | 0.76 | NPC1 (0.41) | LMNAGAAALDH1A1RAB9AKDM4E | |
| SCHEMBL6065290 | 0.71 | DUT (0.30) | — | |
| SCHEMBL6557067 | 0.71 | P2RX3 (0.35) | LMNAL3MBTL1GAAALDH1A1HTT | |
| SCHEMBL6065016 | 0.71 | KMT2A (0.33) | LMNASMN1; SMN2RAB9A | |
| SCHEMBL6557418 | 0.70 | HSD17B10 (0.36) | LMNACYP2C19GAAALDH1A1HTT | |
| SCHEMBL6558372 | 0.69 | POLB (0.43) | LMNAALDH1A1SMN1; SMN2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663245-A1 | CEPHEM COMPOUNDS | Astellas Pharma Inc. (JP) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005027909-A1 | CEPHEM COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2005-03-31 | — | — | WO | disclosed |