SCHEMBL609849

SCHEMBL609849

O=C(O)c1cc(NCCCc2ccc([N+](=O)[O-])cc2)ccc1O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.58
MAPT P10636 4/20 0.58
KMT2A Q03164 2/20 0.58
NPC1 O15118 2/20 0.58
MEN1 O00255 1/20 0.58
TRPA1 O75762 1/20 0.58
LMNA P02545 1/20 0.58
CYP1A2 P05177 1/20 0.58
CYP2C9 P11712 1/20 0.58
TSHR P16473 1/20 0.58
CDK2 P24941 1/20 0.58
MAPK1 P28482 1/20 0.58
THPO P40225 1/20 0.58
BLM P54132 1/20 0.58
PMP22 Q01453 1/20 0.58
HSD17B10 Q99714 1/20 0.58
HDAC6 Q9UBN7 1/20 0.58
LDHA P00338 2/20 0.51
LDHB P07195 1/20 0.51
HAO1 Q9UJM8 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29388237 1.00 ALDH1A1 (0.58) ALDH1A1MAPTKMT2ANPC1MEN1
SCHEMBL29390925 0.93 MAPT (0.56) ALDH1A1MAPTKMT2ANPC1MEN1
SCHEMBL609284 0.93 MAPT (0.56) ALDH1A1MAPTKMT2ANPC1MEN1
SCHEMBL29388556 0.85 KDM4C (0.67) ALDH1A1MAPTKMT2AMEN1LDHA
SCHEMBL611465 0.85 KDM4C (0.67) ALDH1A1MAPTKMT2AMEN1LDHA
SCHEMBL29390491 0.84 PPARA (0.68) ALDH1A1MAPTKMT2ANPC1TDP1
SCHEMBL607642 0.84 PPARA (0.68) ALDH1A1MAPTKMT2ANPC1TDP1
SCHEMBL610427 0.83 SYK (0.59) ALDH1A1MAPTKMT2ANPC1MEN1
SCHEMBL608860 0.83 MCL1 (0.58) ALDH1A1MAPTCYP1A2CYP2C9TSHR
SCHEMBL12086223 0.81 LCK (0.64) ALDH1A1MAPTKMT2ANPC1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3902536-B1 COMPOSITIONS COMPRISING 5-BENZYLAMINOSALICYLIC ACID COMPOUNDS FOR USE IN TREATING NEURODEGENERATIVE DISORDERS IN A COMPANION ANIMAL GNT PHARMA CO LTD (KR) 2025-09-03 EP claimed
EP-4456890-A2 COMPOSITIONS AND METHODS FOR TREATING PULMONARY DISORDERS GNT Pharma Co., Ltd (KR) 2024-11-06 EP claimed
WO-2023156808-A2 COMPOSITIONS AND METHODS FOR TREATING PULMONARY DISORDERS GNT PHARMA CO., LTD. (KR) 2023-08-24 WO claimed
US-20230233503-A1 COMPOSITIONS AND METHODS FOR TREATING PULMONARY DISORDERS GNT PHARMA CO., LTD. (KR) 2023-07-27 US claimed
US-20220249343-A1 COSMETIC COMPOSITION INCLUDING 5-BENZYLAMINOSALICYLIC ACID DERIVATIVE, AND TOPICAL USE THEREOF GNT PHARMA CO., LTD. (KR) 2022-08-11 US claimed
US-20220241231-A1 COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS GNT PHARMA CO., LTD. (KR) 2022-08-04 US claimed
EP-3998058-A1 COSMETIC COMPOSITION COMPRISING 5-BENZYLAMINOSALICYLIC ACID DERIVATIVE AND LOCAL ADMINISTRATION METHOD THEREOF GNT Pharma Co., Ltd (KR) 2022-05-18 EP claimed
CN-114096227-A Cosmetic compositions comprising 5-benzylaminosalicylic acid derivatives and methods of topical use thereof 吉恩特药业株式会社 2022-02-25 CN claimed
CN-113710242-A Compositions and methods for treating neurodegenerative disorders 吉恩特药业株式会社 2021-11-26 CN claimed
US-20200206172-A1 COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS GNT PHARMA CO., LTD. (KR) 2020-07-02 US claimed
US-20120301551-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING NEURONAL DEATH OR NEUROLOGICAL DYSFUNCTION NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2012-11-29 US claimed
US-20120040939-A1 MEDICINAL USE OF 5-BENZYLAMINOSALICYLIC ACID DERIVATIVE OR ITS SALT NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2012-02-16 US claimed
US-20070298129-A1 Compounds and compositions for treating neuronal death or neurological dysfunction NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2007-12-27 US claimed
US-20070049565-A1 Combination of cell necrosis inhibitor and lithium for treating neuronal death or neurological dysfunction NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2007-03-01 US claimed
US-6964982-B2 Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system NEUROTECH CO., LTD. (KR) 2005-11-15 US claimed
EP-1274675-B1 COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING NEURODEGENERATION IN ACUTE AND CHRONIC INJURIES IN THE CENTRAL NERVOUS SYSTEM NEUROTECH CO LTD (KR) 2004-09-01 EP claimed
US-20030045575-A1 Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system NEUROTECH CO., LTD. 2003-03-06 US claimed
EP-1274675-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING NEURODEGENERATION IN ACUTE AND CHRONIC INJURIES IN THE CENTRAL NERVOUS SYSTEM Neurotech Co., Ltd. (KR) 2003-01-15 EP claimed
WO-2001079153-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING NEURODEGENERATION IN ACUTE AND CHRONIC INJURIES IN THE CENTRAL NERVOUS SYSTEM NEUROTECH CO., LTD. (KR) 2001-10-25 WO claimed
EP-3902536-B1 COMPOSITIONS COMPRISING 5-BENZYLAMINOSALICYLIC ACID COMPOUNDS FOR USE IN TREATING NEURODEGENERATIVE DISORDERS IN A COMPANION ANIMAL GNT PHARMA CO LTD (KR) 2025-09-03 EP disclosed
US-12285402-B2 Compositions and methods for treating pulmonary disorders GNT PHARMA CO., LTD. (KR) 2025-04-29 US disclosed
EP-4456890-A2 COMPOSITIONS AND METHODS FOR TREATING PULMONARY DISORDERS GNT Pharma Co., Ltd (KR) 2024-11-06 EP disclosed
WO-2023156808-A2 COMPOSITIONS AND METHODS FOR TREATING PULMONARY DISORDERS GNT PHARMA CO., LTD. (KR) 2023-08-24 WO disclosed
US-20230233503-A1 COMPOSITIONS AND METHODS FOR TREATING PULMONARY DISORDERS GNT PHARMA CO., LTD. (KR) 2023-07-27 US disclosed
US-20220249343-A1 COSMETIC COMPOSITION INCLUDING 5-BENZYLAMINOSALICYLIC ACID DERIVATIVE, AND TOPICAL USE THEREOF GNT PHARMA CO., LTD. (KR) 2022-08-11 US disclosed
US-20220241231-A1 COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS GNT PHARMA CO., LTD. (KR) 2022-08-04 US disclosed
EP-3998058-A1 COSMETIC COMPOSITION COMPRISING 5-BENZYLAMINOSALICYLIC ACID DERIVATIVE AND LOCAL ADMINISTRATION METHOD THEREOF GNT Pharma Co., Ltd (KR) 2022-05-18 EP disclosed
CN-114096227-A Cosmetic compositions comprising 5-benzylaminosalicylic acid derivatives and methods of topical use thereof 吉恩特药业株式会社 2022-02-25 CN disclosed
CN-113710242-A Compositions and methods for treating neurodegenerative disorders 吉恩特药业株式会社 2021-11-26 CN disclosed
WO-2021006637-A1 COSMETIC COMPOSITION COMPRISING 5-BENZYLAMINOSALICYLIC ACID DERIVATIVE AND LOCAL ADMINISTRATION METHOD THEREOF 주식회사 지엔티파마 2021-01-14 WO disclosed
US-20200206172-A1 COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS GNT PHARMA CO., LTD. (KR) 2020-07-02 US disclosed
EP-2004164-B1 PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING INFLAMMATORY DISEASES NEUROTECH PHARMACEUTICALS CO LTD (KR) 2018-08-08 EP disclosed
EP-2394645-B1 Medical use of 5-benzylamino salicylic acid derivatives or salts thereof NEUROTECH PHARMACEUTICALS CO LTD (KR) 2014-10-08 EP disclosed
US-8598383-B2 Pharmaceutical composition for treating or preventing degenerative and inflammatory diseases NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2013-12-03 US disclosed
US-20130316988-A1 Pharmaceutical Composition for Treating or Preventing Degenerative and Inflammatory Diseases NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2013-11-28 US disclosed
US-8455470-B2 Pharmaceutical composition for treating or preventing degenerative and inflammatory diseases NEUROTECH PHARMACEUTICALS CO., LTD (KR) 2013-06-04 US disclosed
US-20120301551-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING NEURONAL DEATH OR NEUROLOGICAL DYSFUNCTION NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2012-11-29 US disclosed
US-20120209025-A1 Pharmaceutical Composition for Treating or Preventing Degenerative and Inflammatory Diseases GWAG BYOUNG-JOO (KR) 2012-08-16 US disclosed
US-8211878-B2 Method for reducing neuronal death in nervous system injuries resulting from amyotrophic lateral sclerosis NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2012-07-03 US disclosed
US-8211878-B2 Method for reducing neuronal death in nervous system injuries resulting from amyotrophic lateral sclerosis NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2012-07-03 US disclosed
US-8211877-B2 Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2012-07-03 US disclosed
US-8211877-B2 Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2012-07-03 US disclosed
US-20120040939-A1 MEDICINAL USE OF 5-BENZYLAMINOSALICYLIC ACID DERIVATIVE OR ITS SALT NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2012-02-16 US disclosed
US-20100331284-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING NEURODEGENERATION IN ACUTE AND CHRONIC INJURIES IN THE CENTRAL NERVOUS SYSTEM NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2010-12-30 US disclosed
US-20100331284-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING NEURODEGENERATION IN ACUTE AND CHRONIC INJURIES IN THE CENTRAL NERVOUS SYSTEM NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2010-12-30 US disclosed
US-20100323995-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING NEURODEGENERATION IN ACUTE AND CHRONIC INJURIES IN THE CENTRAL NERVOUS SYSTEM NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2010-12-23 US disclosed
US-20100323995-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING NEURODEGENERATION IN ACUTE AND CHRONIC INJURIES IN THE CENTRAL NERVOUS SYSTEM NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2010-12-23 US disclosed
US-7750045-B2 Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2010-07-06 US disclosed
US-7750045-B2 Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2010-07-06 US disclosed
US-20090281181-A1 Pharmaceutical Composition for Treating or Preventing Degenerative and Inflammatory Diseases GNT PHARMA CO., LTD. (KR) 2009-11-12 US disclosed
US-20090240079-A1 Pharmaceutical Composition for Treating or Preventing Degenerative and Inflammatory Diseases NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2009-09-24 US disclosed
US-20090149542-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING NEURONAL DEATH OR NEUROLOGICAL DYSFUNCTION NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2009-06-11 US disclosed
EP-2004164-A1 PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING DEGENERATIVE AND INFLAMMATORY DISEASES Neurotech Co., Ltd. (KR) 2008-12-24 EP disclosed
US-20070298129-A1 Compounds and compositions for treating neuronal death or neurological dysfunction NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2007-12-27 US disclosed
WO-2007119973-A1 PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING DEGENERATIVE AND INFLAMMATORY DISEASES NEUROTECH CO., LTD. (KR) 2007-10-25 WO disclosed
US-20070049565-A1 Combination of cell necrosis inhibitor and lithium for treating neuronal death or neurological dysfunction NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2007-03-01 US disclosed
US-20060128677-A1 Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system NEUROTECH CO., LTD. 2006-06-15 US disclosed
US-6964982-B2 Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system NEUROTECH CO., LTD. (KR) 2005-11-15 US disclosed
EP-1274675-B1 COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING NEURODEGENERATION IN ACUTE AND CHRONIC INJURIES IN THE CENTRAL NERVOUS SYSTEM NEUROTECH CO LTD (KR) 2004-09-01 EP disclosed
US-6573402-B1 5-benzylamino salicylic acid and its derivatives as neuroprotective agents NEUROTECH CO., LTD. (KR) 2003-06-03 US disclosed
US-20030097018-A1 Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system NEUROTECH CO., LTD. 2003-05-22 US disclosed
US-20030045575-A1 Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system NEUROTECH CO., LTD. 2003-03-06 US disclosed
EP-1274675-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING NEURODEGENERATION IN ACUTE AND CHRONIC INJURIES IN THE CENTRAL NERVOUS SYSTEM Neurotech Co., Ltd. (KR) 2003-01-15 EP disclosed
WO-2001079153-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING NEURODEGENERATION IN ACUTE AND CHRONIC INJURIES IN THE CENTRAL NERVOUS SYSTEM NEUROTECH CO., LTD. (KR) 2001-10-25 WO disclosed
WO-2001079153-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING NEURODEGENERATION IN ACUTE AND CHRONIC INJURIES IN THE CENTRAL NERVOUS SYSTEM NEUROTECH CO., LTD. (KR) 2001-10-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (19 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090149542-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING NEURONAL DEATH OR NEUROLOGICAL DYSFUNCTION BCL2, BAX, SMN1; SMN2 ALDH1A1 1961/4885MAPT 28/4885KMT2A 4093/4885
US-20120301551-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING NEURONAL DEATH OR NEUROLOGICAL DYSFUNCTION BCL2, BAX, SMN1; SMN2 ALDH1A1 1961/4885MAPT 28/4885KMT2A 4093/4885
US-20230233503-A1 COMPOSITIONS AND METHODS FOR TREATING PULMONARY DISORDERS HAO2, ACOX1, HAO1 ALDH1A1 309/4885MAPT 3976/4885KMT2A 1778/4885
US-20120209025-A1 Pharmaceutical Composition for Treating or Preventing Degenerative and Inflammatory Diseases ALOX12, ALOX15, ALOX15B ALDH1A1 446/4885MAPT 654/4885KMT2A 3791/4885
US-20220241231-A1 COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS PRNP, PSEN1, GRIK5 ALDH1A1 859/4885MAPT 19/4885KMT2A 4255/4885
US-20100331284-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING NEURODEGENERATION IN ACUTE AND CHRONIC INJURIES IN THE CENTRAL NERVOUS SYSTEM GRIK5, GRIN1, GRIN3A ALDH1A1 762/4885MAPT 216/4885KMT2A 1785/4885
US-12285402-B2 Compositions and methods for treating pulmonary disorders HAO2, ACOX1, HAO1 ALDH1A1 309/4885MAPT 3976/4885KMT2A 1778/4885
US-20090240079-A1 Pharmaceutical Composition for Treating or Preventing Degenerative and Inflammatory Diseases ALOX12, ALOX15, ALOX15B ALDH1A1 446/4885MAPT 654/4885KMT2A 3791/4885
US-20100323995-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING NEURODEGENERATION IN ACUTE AND CHRONIC INJURIES IN THE CENTRAL NERVOUS SYSTEM GRIK5, GRIN1, GRIN3A ALDH1A1 762/4885MAPT 216/4885KMT2A 1785/4885
US-20070298129-A1 Compounds and compositions for treating neuronal death or neurological dysfunction BCL2, BAX, SMN1; SMN2 ALDH1A1 1961/4885MAPT 28/4885KMT2A 4093/4885
US-20120040939-A1 MEDICINAL USE OF 5-BENZYLAMINOSALICYLIC ACID DERIVATIVE OR ITS SALT HTR5A, HTR6, MC5R ALDH1A1 133/4885MAPT 2420/4885KMT2A 1429/4885
US-20090281181-A1 Pharmaceutical Composition for Treating or Preventing Degenerative and Inflammatory Diseases ALOX12, ALOX15, ALOX15B ALDH1A1 446/4885MAPT 654/4885KMT2A 3791/4885
US-20030097018-A1 Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system GRIK5, GRIN2A, GRIN2C ALDH1A1 831/4885MAPT 184/4885KMT2A 981/4885
US-20130316988-A1 Pharmaceutical Composition for Treating or Preventing Degenerative and Inflammatory Diseases ALOX12, ALOX15, ALOX15B ALDH1A1 446/4885MAPT 654/4885KMT2A 3791/4885
US-20070049565-A1 Combination of cell necrosis inhibitor and lithium for treating neuronal death or neurological dysfunction BAD, MAP1LC3B, XIAP ALDH1A1 2762/4885MAPT 33/4885KMT2A 4782/4885
US-20220249343-A1 COSMETIC COMPOSITION INCLUDING 5-BENZYLAMINOSALICYLIC ACID DERIVATIVE, AND TOPICAL USE THEREOF ALOX5, ALOX15, IL5 ALDH1A1 93/4885MAPT 3381/4885KMT2A 2648/4885
US-20030045575-A1 Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system GRIK5, GRIN2A, GRIN2C ALDH1A1 831/4885MAPT 184/4885KMT2A 981/4885
US-20060128677-A1 Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system GRIK5, GRIN1, GRIN3A ALDH1A1 762/4885MAPT 216/4885KMT2A 1785/4885
US-20200206172-A1 COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS PRNP, PSEN1, GRIK5 ALDH1A1 859/4885MAPT 19/4885KMT2A 4255/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.