Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.38 |
| ▸ | CTSV | O60911 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6154193 | 0.82 | CCKBR (0.64) | CCKBRNFE2L2PSEN1PSEN2APH1B | |
| SCHEMBL6154302 | 0.81 | CCKBR (0.46) | CCKBRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL30104893 | 0.74 | CCKBR (0.41) | CCKBRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6153909 | 0.69 | CCKBR (0.59) | CCKBRNFE2L2PSEN1PSEN2APH1B | |
| SCHEMBL28735046 | 0.69 | ALDH1A1 (0.46) | CCKBRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL30104872 | 0.67 | POLB (0.38) | CCKBRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6339854 | 0.67 | CCKBR (0.44) | CCKBRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL30104874 | 0.66 | CCKBR (0.59) | CCKBRNFE2L2PSEN1PSEN2APH1B | |
| SCHEMBL30104840 | 0.65 | NR2E3 (0.37) | CCKBRCTSBALDH1A1MAPTLMNA | |
| SCHEMBL6153660 | 0.64 | CASP1 (0.42) | CCKBRNFE2L2PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924377-B2 | Process for preparing highly functionalized γ-butyrolactams and γ-amino acids | WARNER-LAMBERT COMPANY (US) | 2005-08-02 | — | — | US | disclosed |
| EP-1499583-A1 | PROCESS FOR PREPARING HIGHLY FUNCTIONALIZED Y-BUTYROLACTAMS AND Y-AMINO ACIDS | Warner-Lambert Company LLC (US) | 2005-01-26 | — | — | EP | disclosed |
| US-20030236415-A1 | Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids | BLAZECKA PETER G (CA) | 2003-12-25 | — | — | US | disclosed |
| US-20030225149-A1 | Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids | BLAZECKA PETER G (CA) | 2003-12-04 | — | — | US | disclosed |
| WO-2003093220-A1 | PROCESS FOR PREPARING HIGHLY FUNCTIONALIZED Y-BUTYROLACTAMS AND Y-AMINO ACIDS | WARNER-LAMBERT COMPANY LLC (US) | 2003-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236415-A1 | Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids | GABRB2, GABRG2, GABRB1 | CCKBR 208/4885NFE2L2 3337/4885PSEN1 705/4885 |
| US-20030225149-A1 | Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids | GABRB2, GABRG2, GABRB1 | CCKBR 208/4885NFE2L2 3337/4885PSEN1 705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.