Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4873615 | 0.79 | LMNA (0.34) | TP53LMNAPKMPOLBMAPT | |
| SCHEMBL6982440 | 0.79 | PDK1 (0.41) | LMNAPOLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6172702 | 0.77 | PLA2G2A (0.33) | MMP1MMP9 | |
| SCHEMBL4875011 | 0.76 | POLB (0.35) | TP53LMNAPKMPOLBMAPT | |
| SCHEMBL6172262 | 0.75 | LMNA (0.34) | LMNASMN1; SMN2MMP1MMP9 | |
| SCHEMBL6173400 | 0.72 | ACHE (0.31) | LMNASMN1; SMN2 | |
| SCHEMBL6173064 | 0.72 | CCR2 (0.33) | POLBKMT2AMMP1MMP9 | |
| SCHEMBL6172884 | 0.71 | LMNA (0.30) | LMNASMN1; SMN2 | |
| SCHEMBL6173963 | 0.70 | LMNA (0.39) | LMNAPKMPOLBMAPTSMN1; SMN2 | |
| SCHEMBL7085949 | 0.70 | PDK1 (0.35) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-B1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2005-10-26 | — | — | EP | disclosed |