Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 3/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28608040 | 0.78 | PRMT5 (0.39) | ALDH1A1BRD4LIPGPRMT5WDR77 | |
| SCHEMBL6181740 | 0.77 | MMP14 (0.57) | — | |
| SCHEMBL8348574 | 0.75 | AOC3 (0.34) | ITGB3ITGAVALDH1A1NPSR1ITGA2B | |
| SCHEMBL8091141 | 0.73 | CNR2 (0.62) | ITGB3ALDH1A1LTA4HITGA2BCNR2 | |
| SCHEMBL6440847 | 0.72 | ADAM17 (0.51) | ALDH1A1NPSR1AOC3ADAM17PRMT5 | |
| SCHEMBL31666958 | 0.71 | CYP26A1 (0.51) | ITGB3ITGA2BADAM17PRMT5WDR77 | |
| SCHEMBL2499130 | 0.71 | GRM5 (0.46) | ALDH1A1ADAM17CNR2LIPGPRMT5 | |
| SCHEMBL31409528 | 0.70 | ADAM17 (0.48) | ALDH1A1NPSR1ADAM17PRMT5WDR77 | |
| SCHEMBL25365239 | 0.69 | ITGB3 (0.56) | ITGB3ITGAVITGA2BKMT2A | |
| SCHEMBL30530761 | 0.69 | ITGB3 (0.56) | ITGB3ITGAVITGA2BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6919332-B2 | N-substituted-heteroaryloxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors | PFIZER INC. (US) | 2005-07-19 | — | — | US | disclosed |
| EP-1507535-A1 | PYRIMIDINE-2,4,6-TRIONE METALLO-PROTEINASE INHIBITORS | Pfizer Products Inc. (US) | 2005-02-23 | — | — | EP | disclosed |
| US-20030232849-A1 | N-substituted-heteroaryloxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors | PFIZER INC. | 2003-12-18 | — | — | US | disclosed |
| WO-2003090751-A1 | PYRIMIDINE-2, 4, 6-TRIONE METALLO-PROTEINASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2003-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030232849-A1 | N-substituted-heteroaryloxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors | MMP8, MMP9, MMP1 | ITGB3 1804/4885ITGAV 3118/4885ALDH1A1 390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.