Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | PRF1 | P14222 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TYMS | P04818 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204829 | 0.88 | CYP3A4 (0.52) | CYP3A4KDM4EACHEMAPTLMNA | |
| SCHEMBL30773512 | 0.86 | ALOX5 (0.50) | CYP3A4KDM4EACHEMAPTLMNA | |
| SCHEMBL13412837 | 0.82 | CYP3A4 (0.63) | CYP3A4KDM4EMAPTLMNAGAA | |
| SCHEMBL31123684 | 0.77 | PKM (0.68) | KDM4EACHEMAPTGAAMAOA | |
| SCHEMBL584570 | 0.75 | KDM4E (0.41) | CYP3A4KDM4EACHEMAPTLMNA | |
| SCHEMBL17024492 | 0.73 | ALOX5 (0.46) | CYP3A4KDM4EACHEMAPTLMNA | |
| SCHEMBL4110876 | 0.73 | ALOX5 (0.47) | CYP3A4KDM4EACHEALOX5ALDH1A1 | |
| SCHEMBL855514 | 0.72 | CYP3A4 (0.53) | CYP3A4KDM4EMAPTLMNAGAA | |
| SCHEMBL78883 | 0.72 | CYP3A4 (0.53) | CYP3A4KDM4EMAPTLMNAGAA | |
| SCHEMBL1608218 | 0.72 | CYP3A4 (0.53) | CYP3A4KDM4EMAPTLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150045564-A1 | Cu-MEDIATED ANNULATION FOR THE EFFECTIVE SYNTHESIS OF 3-SUBSTITUTED PHTHALIDES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-02-12 | — | — | US | claimed |
| WO-2013102935-A2 | Cu-MEDIATED ANNULATION FOR THE EFFECTIVE SYNTHESIS OF 3-SUBSTITUTED PHTHALIDES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2013-07-11 | — | — | WO | claimed |
| US-9796753-B2 | N-substituted indenoisoquinolines and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2017-10-24 | — | — | US | disclosed |
| US-9796753-B2 | N-substituted indenoisoquinolines and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2017-10-24 | — | — | US | disclosed |
| US-9682990-B2 | Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors | PURDUE RESEARCH FOUNDATION (US) | 2017-06-20 | — | — | US | disclosed |
| US-9682990-B2 | Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors | PURDUE RESEARCH FOUNDATION (US) | 2017-06-20 | — | — | US | disclosed |
| US-20160318946-A1 | ALCOHOL-, DIOL-, AND CARBOHYDRATE-SUBSTITUTED INDENOISOQUINOLINES AS TOPOISOMERASE I INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-11-03 | — | — | US | disclosed |
| US-20160318946-A1 | ALCOHOL-, DIOL-, AND CARBOHYDRATE-SUBSTITUTED INDENOISOQUINOLINES AS TOPOISOMERASE I INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-11-03 | — | — | US | disclosed |
| US-20160229888-A1 | N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-08-11 | — | — | US | disclosed |
| US-20160229888-A1 | N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-08-11 | — | — | US | disclosed |
| US-9402842-B2 | Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (Tdp1)—topoisomerase I (Top1) inhibitors | PURDUE RESEARCH FOUNDATION (US) | 2016-08-02 | — | — | US | disclosed |
| US-8912213-B2 | Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (TDP1)- topoisomerase I (TOP1) inhibitors | PURDUE RESEARCH FOUNDATION (US) | 2014-12-16 | — | — | US | disclosed |
| US-20130345252-A1 | SYNTHESIS AND USE OF DUAL TYROSYL-DNA PHOSPHODIESTERASE I (TDP1)- TOPOISOMERASE I (TOP1) INHIBITORS | PURDUE RESEARCH FOUNDATION | 2013-12-26 | — | — | US | disclosed |
| WO-2013102935-A2 | Cu-MEDIATED ANNULATION FOR THE EFFECTIVE SYNTHESIS OF 3-SUBSTITUTED PHTHALIDES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2013-07-11 | — | — | WO | disclosed |
| US-20080257188-A1 | INK COMPOSITION, INKJET RECORDING METHOD, PRINTED MATERIAL, PRODUCTION METHOD OF A PLANOGRAPHIC PRINTNG PLATE AND PLANOGRAPHIC PRINTING PLATE | FUJIFILM CORPORATION (JP) | 2008-10-23 | — | — | US | disclosed |
| US-20080257188-A1 | INK COMPOSITION, INKJET RECORDING METHOD, PRINTED MATERIAL, PRODUCTION METHOD OF A PLANOGRAPHIC PRINTNG PLATE AND PLANOGRAPHIC PRINTING PLATE | FUJIFILM CORPORATION (JP) | 2008-10-23 | — | — | US | disclosed |
| EP-1266887-B1 | Indenoindoline derivatives, their process of preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-08-17 | — | — | EP | disclosed |
| US-6627650-B2 | An isomer thereof, or an addition salt thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful as anti- cancer agents. | LES LABORATOIRES SERVIER (FR) | 2003-09-30 | — | — | US | disclosed |
| US-20030125369-A1 | Indeno(1,2-b)indole oximes or indeno(1,2-b) indole hydrazones used as anticancer agent | LES LABORATOIRES SERVIER (FR) | 2003-07-03 | — | — | US | disclosed |
| EP-1266887-A2 | Indenoindoline derivatives, their process of preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2002-12-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030125369-A1 | Indeno(1,2-b)indole oximes or indeno(1,2-b) indole hydrazones used as anticancer agent | IDO1, IDO2, AHR | CYP3A4 390/4885KDM4E 2363/4885ACHE 4241/4885 |
| US-20150045564-A1 | Cu-MEDIATED ANNULATION FOR THE EFFECTIVE SYNTHESIS OF 3-SUBSTITUTED PHTHALIDES | SOD1, AOC2, SOD3 | CYP3A4 637/4885KDM4E 1973/4885ACHE 2423/4885 |
| US-20160318946-A1 | ALCOHOL-, DIOL-, AND CARBOHYDRATE-SUBSTITUTED INDENOISOQUINOLINES AS TOPOISOMERASE I INHIBITORS | TOP1, TOP2A, TOP2B | CYP3A4 477/4885KDM4E 1131/4885ACHE 591/4885 |
| US-20130345252-A1 | SYNTHESIS AND USE OF DUAL TYROSYL-DNA PHOSPHODIESTERASE I (TDP1)- TOPOISOMERASE I (TOP1) INHIBITORS | TDP1, TOP1, TDP2 | CYP3A4 1296/4885KDM4E 1092/4885ACHE 763/4885 |
| US-20160229888-A1 | N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF | GNAQ, NRAS, NPM1 | CYP3A4 65/4885KDM4E 926/4885ACHE 1464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.