Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 7/20 | 0.38 |
| ▸ | MMP12 | P39900 | 7/20 | 0.38 |
| ▸ | MMP8 | P22894 | 6/20 | 0.38 |
| ▸ | MMP13 | P45452 | 6/20 | 0.38 |
| ▸ | MMP14 | P50281 | 6/20 | 0.38 |
| ▸ | MMP16 | P51512 | 6/20 | 0.38 |
| ▸ | MMP9 | P14780 | 6/20 | 0.38 |
| ▸ | MMP1 | P03956 | 4/20 | 0.38 |
| ▸ | MMP3 | P08254 | 4/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6201198 | 0.84 | AR (0.36) | MMP13MMP9MMP1L3MBTL1CNR2 | |
| SCHEMBL6202055 | 0.83 | CNR1 (0.38) | LTA4HCNR2CNR1ALDH1A1 | |
| SCHEMBL6201097 | 0.83 | CNR1 (0.38) | LTA4HCNR2CNR1ALDH1A1 | |
| SCHEMBL6202677 | 0.83 | TBXA2R (0.40) | KMT2AMEN1L3MBTL1CNR2CNR1 | |
| SCHEMBL8893617 | 0.76 | CNR1 (0.34) | MMP13MMP9MMP1L3MBTL1CNR2 | |
| SCHEMBL8202222 | 0.76 | CNR1 (0.38) | MMP2MMP13MMP1MMP3ADAM17 | |
| SCHEMBL6203147 | 0.73 | RET (0.33) | KMT2AMEN1L3MBTL1MAPT | |
| SCHEMBL6202226 | 0.72 | ALDH1A1 (0.41) | KMT2AMEN1L3MBTL1HTTALDH1A1 | |
| SCHEMBL6201836 | 0.72 | ALDH1A1 (0.44) | KMT2AMEN1L3MBTL1CNR2HTT | |
| SCHEMBL3659180 | 0.70 | LTA4H (0.51) | MMP2MMP12MMP8MMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425279-A4 | METHOD FOR THE PREPARATION OF CRYSTALLINE TETRAHYDROBENZOTHIEPINES | SEARLE LLC (US) | 2005-10-26 | — | — | EP | disclosed |
| US-20050090543-A1 | Method for the preparation of tetrahydrobenzothiepines | PHARMACIA CORPORATION (US) | 2005-04-28 | — | — | US | disclosed |
| US-6794544-B2 | APICAL SODIUM CO- DEPENDENT BILE ACID TRANSPORTER (ASBT) INHIBITORS | PHARMACIA CORPORATION | 2004-09-21 | — | — | US | disclosed |
| US-20040110761-A1 | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders | G.D. SEARLE LLC | 2004-06-10 | — | — | US | disclosed |
| EP-1425279-A2 | METHOD FOR THE PREPARATION OF CRYSTALLINE TETRAHYDROBENZOTHIEPINES | G.D. Searle LLC (US) | 2004-06-09 | — | — | EP | disclosed |
| US-20040082647-A1 | Method for the preparation of tetrahydrobenzothiepines | G.D. SEARLE, LLC | 2004-04-29 | — | — | US | disclosed |
| US-20030236406-A1 | Method for the preparation of tetrahydrobenzothiepines | BABIAK KEVIN A (US) | 2003-12-25 | — | — | US | disclosed |
| US-20030232834-A1 | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders | KELLER BRADLEY T (US) | 2003-12-18 | — | — | US | disclosed |
| WO-2003022804-A9 | METHOD FOR THE PREPARATION OF CRYSTALLINE TETRAHYDROBENZOTHIEPINES | SEARLE LLC (US) | 2003-12-18 | — | — | WO | disclosed |
| US-20030199515-A1 | Method for the preparation of crystalline tetrahydrobenzothiepines | G.D. SEARLE, LLC (US) | 2003-10-23 | — | — | US | disclosed |
| US-6586434-B2 | Method for the preparation of tetrahydrobenzothiepines | G.D. SEARLE, LLC | 2003-07-01 | — | — | US | disclosed |
| WO-2003022804-A2 | METHOD FOR THE PREPARATION OF CRYSTALLINE TETRAHYDROBENZOTHIEPINES | G.D. SEARLE LLC (US) | 2003-03-20 | — | — | WO | disclosed |
| EP-1286984-A2 | METHOD FOR THE PREPARATION OF TETRAHYDROBENZOTHIEPINES | Pharmacia Corporation (US) | 2003-03-05 | — | — | EP | disclosed |
| US-20020061888-A1 | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders | G.D. SEARLE LLC | 2002-05-23 | — | — | US | disclosed |
| US-20020032329-A1 | Method for the preparation of tetrahydrobenzothiepines | G.D. SEARLE LLC | 2002-03-14 | — | — | US | disclosed |
| WO-2001068637-A2 | METHOD FOR THE PREPARATION OF TETRAHYDROBENZOTHIEPINES | PHARMACIA CORPORATION (US) | 2001-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110761-A1 | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders | SLC10A1, HMGCR, SLC10A2 | MMP2 1902/4885MMP12 1436/4885MMP8 2704/4885 |
| US-20030199515-A1 | Method for the preparation of crystalline tetrahydrobenzothiepines | TPMT, MPST, SULT1A1 | MMP2 3175/4885MMP12 4550/4885MMP8 3976/4885 |
| US-20030232834-A1 | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders | TOP2A, TOP2B, TYMP | MMP2 357/4885MMP12 610/4885MMP8 845/4885 |
| US-20020032329-A1 | Method for the preparation of tetrahydrobenzothiepines | TMT1A, THOP1, BBOX1 | MMP2 2492/4885MMP12 3570/4885MMP8 3290/4885 |
| US-20020061888-A1 | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders | SLC10A1, HMGCR, SLC10A2 | MMP2 2275/4885MMP12 1296/4885MMP8 2730/4885 |
| US-20050090543-A1 | Method for the preparation of tetrahydrobenzothiepines | TMT1A, THOP1, BBOX1 | MMP2 2492/4885MMP12 3570/4885MMP8 3290/4885 |
| US-20030236406-A1 | Method for the preparation of tetrahydrobenzothiepines | TMT1A, THOP1, BBOX1 | MMP2 2456/4885MMP12 3553/4885MMP8 3261/4885 |
| US-20040082647-A1 | Method for the preparation of tetrahydrobenzothiepines | TMT1A, THOP1, BBOX1 | MMP2 2492/4885MMP12 3570/4885MMP8 3290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.