Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 2/20 | 0.77 |
| ▸ | P2RY1 | P47900 | 9/20 | 0.70 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.70 |
| ▸ | P2RY11 | Q96G91 | 3/20 | 0.70 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.70 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.70 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.70 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.70 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.68 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.66 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.66 |
| ▸ | SRC | P12931 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | RNASEL | Q05823 | 2/20 | 0.66 |
| ▸ | GPR17 | Q13304 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14948859 | 1.00 | NT5E (0.77) | NT5EP2RY1P2RX3P2RY11ENPP1 | |
| SCHEMBL625828 | 0.92 | P2RY1 (0.79) | NT5EP2RY1P2RX3P2RY11ENPP1 | |
| SCHEMBL17211052 | 0.92 | P2RY1 (0.79) | NT5EP2RY1P2RX3P2RY11ENPP1 | |
| SCHEMBL12932283 | 0.92 | P2RY1 (0.79) | NT5EP2RY1P2RX3P2RY11ENPP1 | |
| SCHEMBL3502237 | 0.92 | P2RY1 (0.79) | NT5EP2RY1P2RX3P2RY11ENPP1 | |
| SCHEMBL29471291 | 0.92 | P2RY1 (0.79) | NT5EP2RY1P2RX3P2RY11ENPP1 | |
| SCHEMBL18269547 | 0.92 | P2RY1 (0.79) | NT5EP2RY1P2RX3P2RY11ENPP1 | |
| SCHEMBL13857854 | 0.92 | P2RY1 (0.79) | NT5EP2RY1P2RX3P2RY11ENPP1 | |
| SCHEMBL15305345 | 0.91 | NT5E (0.84) | NT5EP2RY1P2RY11P2RY2SRC | |
| SCHEMBL16474336 | 0.91 | NT5E (0.84) | NT5EP2RY1P2RY11P2RY2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 896 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11998601-B2 | Messenger RNA therapy for treatment of articular disease | TRANSLATE BIO, INC. (US) | 2024-06-04 | — | — | US | claimed |
| EP-3115064-B1 | RNA-CODED ANTIBODY | CUREVAC AG (DE) | 2021-11-24 | — | — | EP | claimed |
| US-11110156-B2 | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen | CUREVAC AG (DE) | 2021-09-07 | — | — | US | claimed |
| US-20210060181-A1 | NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED THERAPEUTIC PROTEIN | CUREVAC AG (DE) | 2021-03-04 | — | — | US | claimed |
| US-20210060175-A1 | METHODS OF IMMUNOSTIMULATION WITH COMPLEXES OF RNA AND CATIONIC CARRIERS | CUREVAC AG (DE) | 2021-03-04 | — | — | US | claimed |
| US-10898589-B2 | Nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein | Cure Vac AG (DE) | 2021-01-26 | — | — | US | claimed |
| US-10799602-B2 | Method for increasing expression of RNA-encoded proteins | CUREVAC AG (DE) | 2020-10-13 | — | — | US | claimed |
| US-10738306-B2 | Artificial nucleic acid molecules for improved protein or peptide expression | CUREVAC AG (DE) | 2020-08-11 | — | — | US | claimed |
| US-10653799-B2 | Nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal for increasing the expression of an encoded protein | CUREVAC AG (DE) | 2020-05-19 | — | — | US | claimed |
| EP-3636669-A1 | RNA-CODED ANTIBODY | CureVac AG (DE) | 2020-04-15 | — | — | EP | claimed |
| US-20160145346-A1 | RNA-CODED ANTIBODY | CUREVAC AG (DE) | 2016-05-26 | — | — | US | claimed |
| US-9234013-B2 | Nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal for increasing the expression of an encoded protein | CUREVAC AG (DE) | 2016-01-12 | — | — | US | claimed |
| US-20150184195-A1 | ARTIFICIAL NUCLEIC ACID MOLECULES | CUREVAC GMBH (DE) | 2015-07-02 | — | — | US | claimed |
| US-20150165006-A1 | NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED ALLERGENIC ANTIGEN OR AN AUTOIMMUNE SELF-ANTIGEN | Cure GmbH (DE) | 2015-06-18 | — | — | US | claimed |
| US-20150093413-A1 | NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED PATHOGENIC ANTIGEN | CUREVAC GMBH (DE) | 2015-04-02 | — | — | US | claimed |
| US-20130195867-A1 | RNA-CODED ANTIBODY | CUREVAC GMBH (DE) | 2013-08-01 | — | — | US | claimed |
| US-20100189729-A1 | RNA-CODED ANTIBODY | CURVAC GMBH (DE) | 2010-07-29 | — | — | US | claimed |
| US-20100047261-A1 | BASE-MODIFIED RNA FOR INCREASING THE EXPRESSION OF A PROTEIN | CUREVAC GMBH (DE) | 2010-02-25 | — | — | US | claimed |
| EP-2083851-A2 | (BASE-)MODIFIED RNA FOR INCREASING THE EXPRESSION OF A PROTEIN | Curevac GmbH (DE) | 2009-08-05 | — | — | EP | claimed |
| WO-2008052770-A2 | (BASE-)MODIFIED RNA FOR INCREASING THE EXPRESSION OF A PROTEIN | CUREVAC GMBH (DE) | 2008-05-08 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10653799-B2 | Nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal for increasing the expression of an encoded protein | PARG, PARN, HNRNPH3 | NT5E 891/4885P2RY1 1873/4885P2RX3 1798/4885 |
| US-20150093413-A1 | NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED PATHOGENIC ANTIGEN | HNRNPH3, PARG, CPSF6 | NT5E 455/4885P2RY1 1936/4885P2RX3 1754/4885 |
| US-20160145346-A1 | RNA-CODED ANTIBODY | TRDMT1, NSUN3, POLRMT | NT5E 552/4885P2RY1 3643/4885P2RX3 2501/4885 |
| US-20210060181-A1 | NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED THERAPEUTIC PROTEIN | HNRNPH3, CPSF6, HNRNPL | NT5E 325/4885P2RY1 2048/4885P2RX3 1904/4885 |
| US-20150165006-A1 | NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED ALLERGENIC ANTIGEN OR AN AUTOIMMUNE SELF-ANTIGEN | NASP, H1-5, PARG | NT5E 262/4885P2RY1 1538/4885P2RX3 1492/4885 |
| US-10738306-B2 | Artificial nucleic acid molecules for improved protein or peptide expression | RNMT, NSUN3, RNGTT | NT5E 155/4885P2RY1 2831/4885P2RX3 2043/4885 |
| US-20100047261-A1 | BASE-MODIFIED RNA FOR INCREASING THE EXPRESSION OF A PROTEIN | RNMT, RNASE1, NSUN3 | NT5E 1553/4885P2RY1 4557/4885P2RX3 4449/4885 |
| US-10898589-B2 | Nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein | HNRNPH3, HNRNPL, PABPC1 | NT5E 791/4885P2RY1 3972/4885P2RX3 3766/4885 |
| US-11998601-B2 | Messenger RNA therapy for treatment of articular disease | NSUN3, RNMT, TRDMT1 | NT5E 1205/4885P2RY1 3509/4885P2RX3 2826/4885 |
| US-10799602-B2 | Method for increasing expression of RNA-encoded proteins | STING1, UPF1, CUTA | NT5E 2603/4885P2RY1 3890/4885P2RX3 3742/4885 |
| US-11110156-B2 | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen | HNRNPH3, HNRNPL, CPSF6 | NT5E 281/4885P2RY1 1808/4885P2RX3 1525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.