SCHEMBL6286500

SCHEMBL6286500

CCCc1ccc(OP(=O)([O-])Oc2ccc(CCC)cc2)cc1.[Na+]

nearest known ligand 0.46

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
THRB known ✓ P10828 1/20 0.45
CA2 known ✓ P00918 1/20 0.43
PPARG known ✓ P37231 1/20 0.37
GPR84 Q9NQS5 1/20 0.44
CYP2C19 P33261 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
ALDH1A1 P00352 2/20 0.41
PLK1 P53350 1/20 0.41
FDFT1 P37268 1/20 0.40
PLA2G1B P04054 1/20 0.39
KMT2A Q03164 1/20 0.39
ATG4B Q9Y4P1 1/20 0.39
RAB9A P51151 1/20 0.38
LPL P06858 1/20 0.37
LIPG Q9Y5X9 1/20 0.37
PPARA Q07869 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1165619 0.89 CA2 (0.46) THRBGPR84CYP2C19SMN1; SMN2CA2
SCHEMBL1846072 0.85 SMN1; SMN2 (0.59) GPR84CYP2C19SMN1; SMN2CA2ALDH1A1
SCHEMBL672747 0.83 ENPP2 (0.53) THRBSMN1; SMN2CA2ALDH1A1KMT2A
SCHEMBL673710 0.83 ENPP2 (0.53) THRBSMN1; SMN2CA2ALDH1A1KMT2A
SCHEMBL10901180 0.83 ENPP2 (0.53) THRBSMN1; SMN2CA2ALDH1A1KMT2A
SCHEMBL3958992 0.83 ENPP2 (0.53) THRBSMN1; SMN2CA2ALDH1A1KMT2A
SCHEMBL147166 0.83 ENPP2 (0.53) THRBSMN1; SMN2CA2ALDH1A1KMT2A
SCHEMBL3965860 0.83 ENPP2 (0.53) THRBSMN1; SMN2CA2ALDH1A1KMT2A
SCHEMBL21611785 0.83 ENPP2 (0.53) THRBSMN1; SMN2CA2ALDH1A1KMT2A
SCHEMBL672745 0.83 ENPP2 (0.53) THRBSMN1; SMN2CA2ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6914112-B2 Ethylene copolymer and ethylene/α-olefin copolymer composition and propylene polymer composition both containing the ethylene copolymer MITSUI CHEMICAL, INC. (JP) 2005-07-05 US disclosed
US-20050142303-A1 Adhesive resin and adhesive resin compostion for liquid crystalline polymer MITSUI CHEMICALS INC (JP) 2005-06-30 US disclosed
US-20050065302-A1 Olefin polymer and process for preparing the same MITSUI CHEMICALS, INC. 2005-03-24 US disclosed
US-20040143070-A1 Films, compositions and processes INNOVIA FILMS LIMITED (GB) 2004-07-22 US disclosed
US-20030114579-A1 Ethylene copolymer and ethylene/alpha-olefin copolymer composition and propylene polymer composition both containing the ethylene copolymer MITSUI CHEMICALS, INC. (JP) 2003-06-19 US disclosed
US-20030049477-A1 Soft syndiotactic polypropylene composition and molded product MORIZONO KENICHI (JP) 2003-03-13 US disclosed