Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | MPL | P40238 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | ICMT | O60725 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4626532 | 0.88 | ALDH1A1 (0.63) | HTR2AALDH1A1TSHRHPGDNPSR1 | |
| SCHEMBL6116786 | 0.87 | TSHR (0.69) | HTR2AALDH1A1TSHRHPGDNPSR1 | |
| SCHEMBL25139531 | 0.87 | HTR2A (0.58) | HTR2AALDH1A1HPGDNPSR1LMNA | |
| SCHEMBL10123846 | 0.86 | ICMT (0.66) | HTR2ANPSR1LMNAMAPTNR4A2 | |
| SCHEMBL23701747 | 0.84 | ICMT (0.64) | HTR2AALDH1A1TSHRHPGDNPSR1 | |
| SCHEMBL20119825 | 0.84 | HTR2A (0.63) | HTR2AHPGDNPSR1MAPTSMN1; SMN2 | |
| SCHEMBL25139540 | 0.84 | HTR2A (0.55) | HTR2AALDH1A1HPGDNPSR1LMNA | |
| SCHEMBL14564356 | 0.83 | NR4A2 (0.58) | HTR2AALDH1A1HPGDNPSR1LMNA | |
| SCHEMBL6663269 | 0.82 | ALDH1A1 (0.77) | HTR2AALDH1A1TSHRHPGDNPSR1 | |
| SCHEMBL14823139 | 0.82 | PKM (0.70) | HTR2AALDH1A1LMNACYP2C9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3438108-B1 | PHENYL [A]INDOLE[2,3-G]QUINOLIZINE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2022-08-10 | — | — | EP | disclosed |
| CN-109071541-B | Phenyl [ a ] indole [2,3-g ] quinolizine compound, preparation method thereof, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2021-06-18 | — | — | CN | disclosed |
| US-10927107-B2 | Phenyl [a]indole[2,3-g]quinolizine compounds, preparation method therefor, pharmaceutical composition, and applications thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2021-02-23 | — | — | US | disclosed |
| US-20200216435-A1 | BICYCLIC HETEROAROMATIC AMIDE COMPOUNDS FOR USE IN THERAPY | EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) | 2020-07-09 | — | — | US | disclosed |
| US-20200216435-A1 | BICYCLIC HETEROAROMATIC AMIDE COMPOUNDS FOR USE IN THERAPY | EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) | 2020-07-09 | — | — | US | disclosed |
| EP-3638667-A1 | BICYCLIC HETEROAROMATIC AMIDE COMPOUNDS FOR USE IN THERAPY | European Molecular Biology Laboratory (DE) | 2020-04-22 | — | — | EP | disclosed |
| CN-111032653-A | Bicyclic heteroaromatic amide compounds for therapy | 欧洲分子生物学实验室 | 2020-04-17 | — | — | CN | disclosed |
| US-20190194185-A1 | PHENYL [A]INDOLE[2,3-G]QUINOLIZINE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2019-06-27 | — | — | US | disclosed |
| EP-3438108-A1 | PHENYL [A]INDOLE[2,3-G]QUINOLIZINE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2019-02-06 | — | — | EP | disclosed |
| CN-109071541-A | Phenyl [ a ] indole [2,3-g ] quinolizine compound, preparation method thereof, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2018-12-21 | — | — | CN | disclosed |
| US-20150051405-A1 | NEW 1,2,4-OXADIAZOL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND USE THEREOF AS INTERMEDIATES IN THE PREPARATION OF INDOLIC ALKALOIDS | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2015-02-19 | — | — | US | disclosed |
| CN-103347874-B | dimeric IAP inhibitors | NOVARTIS AG (CH) | 2014-10-29 | — | — | CN | disclosed |
| CN-103347874-A | Dimeric iap inhibitors | NOVARTIS AG | 2013-10-09 | — | — | CN | disclosed |
| US-8470786-B2 | Pyrroloquinolinyl-pyrrolidine-2,5-dione compositions and methods for preparing and using same | ARQULE, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20120165278-A1 | Pyrroloquinolinyl-Pyrrolidine-2,5-Dione Compositions And Methods For Preparing And Using Same | ARQULE, INC. (US) | 2012-06-28 | — | — | US | disclosed |
| US-20070054902-A1 | Isoxazole derivatives as peroxisome proliferator-activated receptors agonists | SHIONOGI & CO., LTD. (JP) | 2007-03-08 | — | — | US | disclosed |
| US-20070054902-A1 | Isoxazole derivatives as peroxisome proliferator-activated receptors agonists | SHIONOGI & CO., LTD. (JP) | 2007-03-08 | — | — | US | disclosed |
| US-6887890-B2 | Compounds exhibiting thrombopoietin-like activities | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-05-03 | — | — | US | disclosed |
| US-20030162724-A1 | Compounds exhibiting thrombopoietin-like activities | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-08-28 | — | — | US | disclosed |
| EP-1291341-A1 | COMPOUNDS EXHIBITING THROMBOPOIETIN-LIKE ACTIVITIES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10927107-B2 | Phenyl [a]indole[2,3-g]quinolizine compounds, preparation method therefor, pharmaceutical composition, and applications thereof | PCSK9, PCSK7, PCSK6 | HTR2A 414/4885ALDH1A1 2606/4885TSHR 3140/4885 |
| US-20200216435-A1 | BICYCLIC HETEROAROMATIC AMIDE COMPOUNDS FOR USE IN THERAPY | NR5A1, NR3C2, NR3C1 | HTR2A 1170/4885ALDH1A1 2444/4885TSHR 1638/4885 |
| US-20150051405-A1 | NEW 1,2,4-OXADIAZOL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND USE THEREOF AS INTERMEDIATES IN THE PREPARATION OF INDOLIC ALKALOIDS | IDO1, ADRA1D, PNMT | HTR2A 129/4885ALDH1A1 1777/4885TSHR 4058/4885 |
| US-20030162724-A1 | Compounds exhibiting thrombopoietin-like activities | MPL, THPO, TEK | HTR2A 799/4885ALDH1A1 2042/4885TSHR 435/4885 |
| US-20190194185-A1 | PHENYL [A]INDOLE[2,3-G]QUINOLIZINE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS THEREOF | PCSK9, PCSK7, PCSK6 | HTR2A 414/4885ALDH1A1 2606/4885TSHR 3140/4885 |
| US-20120165278-A1 | Pyrroloquinolinyl-Pyrrolidine-2,5-Dione Compositions And Methods For Preparing And Using Same | DHPS, PDCD5, DPYD | HTR2A 3245/4885ALDH1A1 1136/4885TSHR 4565/4885 |
| US-20070054902-A1 | Isoxazole derivatives as peroxisome proliferator-activated receptors agonists | NR1H3, NR1H2, RXRA | HTR2A 3396/4885ALDH1A1 1698/4885TSHR 176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.