Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 8/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30407649 | 1.00 | AVPR1A (0.51) | AVPR1AGRIN1GRIN2BSIGMAR1 | |
| SCHEMBL6355582 | 0.87 | AVPR1A (0.42) | AVPR1AGRIN1GRIN2B | |
| SCHEMBL9615977 | 0.85 | SIGMAR1 (0.54) | AVPR1ASIGMAR1 | |
| SCHEMBL6346561 | 0.84 | SIGMAR1 (0.55) | AVPR1ASIGMAR1 | |
| SCHEMBL16546758 | 0.82 | SIGMAR1 (0.47) | AVPR1ASIGMAR1 | |
| SCHEMBL30389740 | 0.79 | SIGMAR1 (0.50) | SIGMAR1 | |
| SCHEMBL11328335 | 0.79 | SIGMAR1 (0.50) | SIGMAR1 | |
| SCHEMBL3400315 | 0.78 | SIGMAR1 (0.49) | AVPR1ASIGMAR1 | |
| SCHEMBL29790950 | 0.78 | SIGMAR1 (0.49) | AVPR1ASIGMAR1 | |
| SCHEMBL6819933 | 0.78 | AVPR1A (0.46) | AVPR1AGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116640094-A | Compounds as PRMT1 inhibitors and uses thereof | 南京圣和药业股份有限公司 | 2023-08-25 | — | — | CN | disclosed |
| US-20230257371-A1 | CYCLIC CYANOENONE DERIVATIVES AS MODULATORS OF KEAP1 | MERCK SHARP & DOHME LLC (US) | 2023-08-17 | — | — | US | disclosed |
| WO-2023081666-A1 | COMPOUNDS AS CCR2 MODULATORS | ARIA PHARMACEUTICALS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2023081666-A1 | COMPOUNDS AS CCR2 MODULATORS | ARIA PHARMACEUTICALS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |
| US-11203592-B2 | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-12-21 | — | — | US | disclosed |
| US-11203592-B2 | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-12-21 | — | — | US | disclosed |
| US-20210221806-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE | BRISTOL-MYERS SQUIBB COMPANY | 2021-07-22 | — | — | US | disclosed |
| US-20210221806-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE | BRISTOL-MYERS SQUIBB COMPANY | 2021-07-22 | — | — | US | disclosed |
| WO-2019074824-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-04-18 | — | — | WO | disclosed |
| EP-2419418-B1 | 4-AZETIDINYL-1-HETEROATOM LINKED-CYCLOHEXANE ANTAGONISTS OF CCR2 | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-15 | — | — | EP | disclosed |
| EP-1565436-A4 | 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORP (US) | 2007-07-18 | — | — | EP | disclosed |
| US-20060252751-A1 | 3-Aminopyrrolidine derivaties as modulators of chemokine receptors | INCYTE HOLDINGS CORPORATION | 2006-11-09 | — | — | US | disclosed |
| WO-2006092731-A1 | 1, 2, 4-TRIAZOLE DERIVATIVES AND THEIR USE AS OXYTOCIN ANTAGONISTS | PFIZER LIMTED (GB) | 2006-09-08 | — | — | WO | disclosed |
| EP-0925291-B1 | SPIROCYCLIC DOPAMINE RECEPTOR SUBTYPE LIGANDS | PFIZER (US) | 2005-11-30 | — | — | EP | disclosed |
| US-20050261327-A1 | 2-(Bicyclo)alkylamino-derivatives as mediatores of chronic pain and inflammation | MERCK & CO., INC. | 2005-11-24 | — | — | US | disclosed |
| EP-1565436-A2 | 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORPORATION (US) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004050024-A2 | 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORPORATION (US) | 2004-06-17 | — | — | WO | disclosed |
| US-6664258-B1 | Transphenylpiperazines; central dopaminergic activity | PFIZER INC | 2003-12-16 | — | — | US | disclosed |
| EP-0925291-A1 | SPIROCYCLIC DOPAMINE RECEPTOR SUBTYPE LIGANDS | PFIZER INC. (US) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998008835-A1 | SPIROCYCLIC DOPAMINE RECEPTOR SUBTYPE LIGANDS | PFIZER INC. (US) | 1998-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252751-A1 | 3-Aminopyrrolidine derivaties as modulators of chemokine receptors | CCR2, CXCR3, CCR5 | AVPR1A 300/4885GRIN1 494/4885GRIN2B 942/4885 |
| US-20050261327-A1 | 2-(Bicyclo)alkylamino-derivatives as mediatores of chronic pain and inflammation | BDKRB1, BDKRB2, LTB4R2 | AVPR1A 157/4885GRIN1 372/4885GRIN2B 168/4885 |
| US-11203592-B2 | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use | IDO1, IDO2, INMT | AVPR1A 2969/4885GRIN1 1518/4885GRIN2B 1584/4885 |
| US-20210221806-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE | IDO1, IDO2, INMT | AVPR1A 2969/4885GRIN1 1518/4885GRIN2B 1584/4885 |
| US-20230257371-A1 | CYCLIC CYANOENONE DERIVATIVES AS MODULATORS OF KEAP1 | KEAP1, NFE2L2, NQO1 | AVPR1A 1257/4885GRIN1 3583/4885GRIN2B 3988/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.