Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6326374 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2SIGMAR1MEN1KMT2AOPRK1 | |
| SCHEMBL7024973 | 0.84 | MEN1 (0.48) | SMN1; SMN2SIGMAR1MEN1KMT2AOPRK1 | |
| SCHEMBL6320470 | 0.81 | CALM1 (0.47) | SMN1; SMN2SIGMAR1MEN1KMT2AOPRK1 | |
| SCHEMBL7608480 | 0.80 | L3MBTL1 (0.52) | SMN1; SMN2BCL2 | |
| SCHEMBL11125959 | 0.77 | SMN1; SMN2 (0.57) | SMN1; SMN2SIGMAR1MEN1KMT2AOPRK1 | |
| SCHEMBL7148205 | 0.75 | MEN1 (0.48) | SMN1; SMN2SIGMAR1MEN1KMT2AOPRK1 | |
| SCHEMBL19700321 | 0.73 | PYCR1 (0.55) | MEN1KMT2AHTTPYCR1 | |
| SCHEMBL28827443 | 0.73 | CYP2C9 (0.54) | SMN1; SMN2MEN1KMT2AHTT | |
| SCHEMBL6621416 | 0.73 | FNTA (0.54) | MEN1KMT2AOPRK1PYCR1OPRM1 | |
| SCHEMBL15269721 | 0.73 | MEN1 (0.44) | SIGMAR1MEN1KMT2AOPRK1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050288187-A1 | Inhibitor development for 4-hydroxyphenylpyruvate dioxygenase, employing tyrosinemia 1 as a model for human diseases mediated by 2-oxoacid utilizing dioxygenases | ROCKEFELLER UNIVERSITY, THE | 2005-12-29 | — | — | US | disclosed |
| US-20050043371-A1 | Aminoalcohol derivatives and their use as beta 3 adrenergic agonists | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2005-02-24 | — | — | US | disclosed |
| US-20030181726-A1 | Aminoalcohol derivatives and their use as beta 3 adrenergic agonists | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2003-09-25 | — | — | US | disclosed |
| US-6080766-A | ADMINISTERING TO A PATIENT AN EFFECTIVE AMOUNT OF A HYDROXYPYRROLIDONE COMPOUND TO SUPPRESS THE FORMATION OF COLLAGEN-LIKE SUBSTANCES OR BIOSYNTHESIS OF PROCOLLAGEN | CORNELL RESEARCH FOUNDATION, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| US-6046219-A | ADMINISTERING TO THE PATIENT FOR TREATING THE CONDITIONS MEDIATED BY COLLAGEN FORMATION TOGETHER WITH CELL PROLIFERATION A HYDROXYPYRIDINE DERIVATIVE | CORNELL RESEARCH FOUNDATION, INC. (US) | 2000-04-04 | — | — | US | disclosed |
| US-5965585-A | SUPPRESSING FORMATION OF COLLAGEN AND COLLAGEN-LIKE SUBSTANCES OR BIOSYNTHESIS OF PROCOLLAGEN IN LIVING SYSTEMS BY ADMINISTERING A HYDROXYPYRIDONE COMPOUND ENZYME INHIBITOR OF PROTEIN HYDROXYLASE; ANTISCARRING AGENTS | CORNELL RESEARCH FOUNDATION, INC. (US) | 1999-10-12 | — | — | US | disclosed |
| US-5965586-A | Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation | CORNELL RESEARCH FOUNDATION, INC. (US) | 1999-10-12 | — | — | US | disclosed |
| US-5849587-A | Method of inhibiting viral replication in eukaryotic cells and of inducing apoptosis of virally-infected cells | CORNELL RESEARCH FOUNDATION, INC. (US) | 1998-12-15 | — | — | US | disclosed |
| US-5789426-A | SUPPRESSION FORMATION OF COLLAGEN | CORNELL RESEARCH FOUNDATION, INC. (US) | 1998-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043371-A1 | Aminoalcohol derivatives and their use as beta 3 adrenergic agonists | ADRB1, ADRB3, ADRB2 | SMN1; SMN2 1593/4885SIGMAR1 634/4885MEN1 3533/4885 |
| US-20030181726-A1 | Aminoalcohol derivatives and their use as beta 3 adrenergic agonists | ADRB1, ADRB3, ADRB2 | SMN1; SMN2 1281/4885SIGMAR1 465/4885MEN1 3327/4885 |
| US-20050288187-A1 | Inhibitor development for 4-hydroxyphenylpyruvate dioxygenase, employing tyrosinemia 1 as a model for human diseases mediated by 2-oxoacid utilizing dioxygenases | HPD, TH, PDXK | SMN1; SMN2 3995/4885SIGMAR1 4329/4885MEN1 3574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.