SCHEMBL635306

SCHEMBL635306

O=C1C=CC(=O)N1c1cccc(N2C(=O)C=CC2=O)c1N1C(=O)C=CC1=O

nearest known ligand 0.68

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TLR9 Q9NR96 2/20 0.68
MGLL Q99685 17/20 0.56
FAAH O00519 5/20 0.50
HSP90AA1 P07900 2/20 0.46
ALDH1A1 P00352 1/20 0.46
PKM P14618 1/20 0.46
CCR6 P51684 1/20 0.46
ATM Q13315 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
TDP1 Q9NUW8 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9067136 0.85 MGLL (0.68) TLR9MGLLFAAHHSP90AA1ALDH1A1
SCHEMBL10769331 0.82 MGLL (0.73) TLR9MGLLFAAHHSP90AA1ALDH1A1
SCHEMBL121404 0.81 TLR9 (1.00) TLR9MGLLFAAHHSP90AA1ALDH1A1
SCHEMBL29377102 0.81 TLR9 (1.00) TLR9MGLLFAAHHSP90AA1ALDH1A1
SCHEMBL28343039 0.80 ALDH1A1 (0.56) TLR9MGLLFAAHHSP90AA1ALDH1A1
SCHEMBL28624878 0.80 MGLL (0.73) TLR9MGLLFAAHHSP90AA1ALDH1A1
SCHEMBL3277562 0.80 TLR9 (0.68) TLR9MGLLFAAHHSP90AA1ALDH1A1
SCHEMBL31179969 0.80 TLR9 (0.68) TLR9MGLLFAAHHSP90AA1ALDH1A1
SCHEMBL144793 0.78 MGLL (0.65) TLR9MGLLFAAHHSP90AA1ALDH1A1
SCHEMBL4604629 0.78 MGLL (0.53) TLR9MGLLFAAHHSP90AA1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 225 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11912794-B2 Modulation of structured polypeptide specificity Bicyclerd Limited (GB) 2024-02-27 US claimed
US-20210122786-A1 MODULATION OF STRUCTURED POLYPEPTIDE SPECIFICITY Bicyclerd Limited (GB) 2021-04-29 US claimed
US-10800813-B2 Modulation of structured polypeptide specificity Bicyclerd Limited (GB) 2020-10-13 US claimed
US-20260137791-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR PD-L1 Bicyclerd Limited (GB) 2026-05-21 US disclosed
US-12630588-B2 Bicyclic peptide ligands specific for CD137 BICYCLETX LIMITED (GB) 2026-05-19 US disclosed
US-12551567-B2 Bicyclic peptide ligands specific for PD-L1 Bicyclerd Limited (GB) 2026-02-17 US disclosed
US-12540161-B2 Linkers BICYCLETX LIMITED (GB) 2026-02-03 US disclosed
US-12491253-B2 Bicyclic peptide ligands specific for MT1-MMP Bicyclerd Limited (GB) 2025-12-09 US disclosed
US-20250325672-A1 ANTI-INFECTIVE BICYCLIC PEPTIDE LIGANDS BICYCLE TX LTD (GB) 2025-10-23 US disclosed
US-20250255975-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR MT1-MMP Bicyclerd Limited (GB) 2025-08-14 US disclosed
US-12377155-B2 Bicyclic peptide ligands specific for PSMA Bicyclerd Limited (GB) 2025-08-05 US disclosed
US-20120172235-A1 PEPTIDE LIBRARIES MEDICAL RESEARCH COUNCIL (GB) 2012-07-05 US disclosed
EP-2464727-A2 PEPTIDE LIBRARIES Medical Research Council (GB) 2012-06-20 EP disclosed
US-20120101256-A1 MULTISPECIFIC PEPTIDES MEDICAL RESEARCH COUNCIL (GB) 2012-04-26 US disclosed
EP-2257624-B1 METHODS AND COMPOSITIONS MEDICAL RES COUNCIL (GB) 2012-04-25 EP disclosed
EP-2420255-A2 Polypeptide inhibitors of urokinase type plasminogen activator Ecole Polytechnique Federale De Lausanne (EPFL) (CH) 2012-02-22 EP disclosed
EP-2393519-A1 MULTISPECIFIC PEPTIDES Medical Research Council (GB) 2011-12-14 EP disclosed
WO-2011018227-A2 PEPTIDE LIBRARIES MEDICAL RESEARCH COUNCIL (GB) 2011-02-17 WO disclosed
US-20100317547-A1 METHODS AND COMPOSITIONS MEDICAL RESEARCH COUNCIL 2010-12-16 US disclosed
WO-2010089115-A1 MULTISPECIFIC PEPTIDES MEDICAL RESEARCH COUNCIL (GB) 2010-08-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250325672-A1 ANTI-INFECTIVE BICYCLIC PEPTIDE LIGANDS ACE2, SARS1, TMPRSS2 TLR9 1431/4885MGLL 1540/4885FAAH 2378/4885
US-20120172235-A1 PEPTIDE LIBRARIES MICA, SPPL2B, PTMS TLR9 2208/4885MGLL 3288/4885FAAH 3698/4885
US-12630588-B2 Bicyclic peptide ligands specific for CD137 PTMS, IL36G, HLA-A TLR9 1302/4885MGLL 3904/4885FAAH 2721/4885
US-20250255975-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR MT1-MMP MMEL1, MMP3, TIMP3 TLR9 1652/4885MGLL 2818/4885FAAH 2906/4885
US-12551567-B2 Bicyclic peptide ligands specific for PD-L1 PDCD1LG2, CD274, PDCD1 TLR9 2606/4885MGLL 4463/4885FAAH 4234/4885
US-20260137791-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR PD-L1 PDCD1LG2, CD274, PDCD1 TLR9 610/4885MGLL 4463/4885FAAH 3785/4885
US-10800813-B2 Modulation of structured polypeptide specificity KLKB1, KLK5, KLK1 TLR9 4604/4885MGLL 2429/4885FAAH 3421/4885
US-20120101256-A1 MULTISPECIFIC PEPTIDES TIMCC, MICA, LNPEP TLR9 1897/4885MGLL 3315/4885FAAH 3891/4885
US-12377155-B2 Bicyclic peptide ligands specific for PSMA KLK3, FOLH1, PSMA3 TLR9 1615/4885MGLL 2917/4885FAAH 3284/4885
US-12491253-B2 Bicyclic peptide ligands specific for MT1-MMP MMEL1, MMP3, TIMP3 TLR9 1584/4885MGLL 4053/4885FAAH 3353/4885
US-12540161-B2 Linkers ADM2, CDA, DCTD TLR9 1391/4885MGLL 4027/4885FAAH 134/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.