Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.32 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.30 |
| ▸ | YTHDF2 | Q9Y5A9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19801401 | 0.81 | GRM4 (0.33) | MAPK1GRM4 | |
| SCHEMBL14725583 | 0.78 | ITK (0.33) | ITKGRM4 | |
| SCHEMBL19258970 | 0.77 | YTHDC1 (0.40) | MAPK1GRM4YTHDC1YTHDF2 | |
| SCHEMBL14906033 | 0.75 | MAPK1 (0.45) | MAPK1 | |
| SCHEMBL30876173 | 0.75 | MAPK1 (0.35) | MAPK1 | |
| SCHEMBL30316980 | 0.75 | MAPK1 (0.35) | MAPK1GRM4 | |
| SCHEMBL14763598 | 0.75 | DYRK1A (0.38) | MAPK1 | |
| SCHEMBL30180924 | 0.75 | DYRK1A (0.38) | MAPK1 | |
| SCHEMBL3950985 | 0.75 | PDPK1 (0.38) | MAPK1GRM4YTHDC1YTHDF2 | |
| SCHEMBL29606019 | 0.73 | MAPK1 (0.33) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050070542-A1 | 5-Aryl-pyrazolo[4,3-d]pyrimidines, pyridines, and pyrazines and related compounds | NEUROGEN CORPORATION | 2005-03-31 | — | — | US | claimed |
| US-20050070542-A1 | 5-Aryl-pyrazolo[4,3-d]pyrimidines, pyridines, and pyrazines and related compounds | NEUROGEN CORPORATION | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070542-A1 | 5-Aryl-pyrazolo[4,3-d]pyrimidines, pyridines, and pyrazines and related compounds | CRHR1, HTR5A, HTR1D | MAPK1 1598/4885ITK 3225/4885GRM4 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.