Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 6/20 | 0.60 |
| ▸ | HTR6 | P50406 | 2/20 | 0.60 |
| ▸ | GOT1 | P17174 | 2/20 | 0.54 |
| ▸ | NCF1 | P14598 | 2/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.47 |
| ▸ | HTR3B | O95264 | 4/20 | 0.47 |
| ▸ | HTR3A | P46098 | 4/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5704758 | 0.83 | GOT1 (0.56) | ADRB1HTR6GOT1NCF1DRD2 | |
| SCHEMBL18690971 | 0.81 | HTR6 (0.60) | ADRB1HTR6GOT1NCF1ADRB2 | |
| SCHEMBL31652183 | 0.79 | HTR6 (0.57) | ADRB1HTR6GOT1NCF1ADRB2 | |
| SCHEMBL27421762 | 0.78 | ADRB2 (0.54) | ADRB1HTR6NCF1ADRB2HTR3E | |
| SCHEMBL6637833 | 0.78 | ADRB1 (0.56) | ADRB1HTR6NCF1HTR3EHTR3B | |
| SCHEMBL1012802 | 0.76 | ADRB1 (1.00) | ADRB1HTR6GOT1NCF1HTR3E | |
| SCHEMBL18690899 | 0.74 | GOT1 (0.62) | GOT1GAAMAPTRECQL | |
| Hydrochloric Acid SCHEMBL6730585 | 0.74 | ADRB1 (0.97) | ADRB1HTR6GOT1NCF1HTR3E | |
| Hydrochloric Acid SCHEMBL4662618 | 0.74 | ADRB1 (0.97) | ADRB1HTR6GOT1NCF1HTR3E | |
| SCHEMBL21894610 | 0.74 | HTR7 (0.50) | ADRB1HTR6NCF1ADRB2HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166924-B1 | AROMATIC HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2019-02-20 | — | — | EP | disclosed |
| US-9974785-B2 | Aromatic heterocyclic derivatives and pharmaceutical applications thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2018-05-22 | — | — | US | disclosed |
| US-20170096392-A1 | AROMATIC HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2017-04-06 | — | — | US | disclosed |
| US-20050176705-A1 | Compounds useful in the treatment of cns disorders | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170096392-A1 | AROMATIC HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF | HTR6, HTR3A, HTR5A | ADRB1 67/4885HTR6 1/4885GOT1 1868/4885 |
| US-20050176705-A1 | Compounds useful in the treatment of cns disorders | SLC18A2, CNR2, TPH2 | ADRB1 346/4885HTR6 22/4885GOT1 2552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.