Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 known ✓ | P22748 | 1/20 | 0.32 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.31 |
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.31 |
| ▸ | CA12 known ✓ | O43570 | 1/20 | 0.31 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL8422205 | 0.88 | KDM4E (0.35) | KDM4EMAPTALOX15SMN1; SMN2FFAR3 | |
| SCHEMBL16711938 | 0.77 | CA12 (0.42) | KDM4EMAPTALOX15SMN1; SMN2FFAR3 | |
| SCHEMBL5490571 | 0.77 | KDM4E (0.34) | KDM4EMAPTALOX15SMN1; SMN2FFAR3 | |
| SCHEMBL14589687 | 0.76 | TAS2R38 (0.43) | TAS2R38 | |
| SCHEMBL2449889 | 0.76 | TAS2R38 (0.43) | TAS2R38KDM4EALOX15FFAR3 | |
| SCHEMBL1449766 | 0.73 | ABCB11 (0.32) | KDM4EMAPTALOX15SMN1; SMN2BBOX1 | |
| Potassium Ion SCHEMBL32685233 | 0.73 | CA12 (0.40) | KDM4EMAPTALOX15SMN1; SMN2CA4 | |
| SCHEMBL1616806 | 0.69 | — | — | |
| SCHEMBL150760 | 0.69 | KDM4E (0.42) | KDM4EMAPTALOX15SMN1; SMN2FFAR3 | |
| SCHEMBL9328956 | 0.68 | CA12 (0.58) | TAS2R38KDM4EMAPTALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050064351-A1 | Silver-halide-containing photothermographic element for improved latitude | EASTMAN KODAK COMPANY | 2005-03-24 | — | — | US | disclosed |
| US-20020197572-A1 | HIGH BROMIDE TABULAR GRAIN EMULSIONS PRECIPITATED IN A NOVEL DISPERSING MEDIUM | EASTMAN KODAK COMPANY | 2002-12-26 | — | — | US | disclosed |