Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 10/20 | 0.37 |
| ▸ | CTSS | P25774 | 6/20 | 0.36 |
| ▸ | CTSK | P43235 | 6/20 | 0.36 |
| ▸ | CTSV | O60911 | 3/20 | 0.36 |
| ▸ | CTSB | P07858 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GLI1 | P08151 | 1/20 | 0.35 |
| ▸ | GLI2 | P10070 | 1/20 | 0.35 |
| ▸ | SFN | P31947 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6446599 | 0.92 | GUSB (0.43) | GUSBCTSLCTSSCTSKCTSV | |
| SCHEMBL6822562 | 0.90 | CTSK (0.47) | CTSLCTSSCTSKCTSVCTSB | |
| SCHEMBL6443632 | 0.88 | SFN (0.42) | GUSBCTSLCTSSCTSKGAA | |
| SCHEMBL6446578 | 0.87 | ATM (0.41) | GUSBCTSLCTSSCTSKCTSV | |
| SCHEMBL6443745 | 0.85 | CTSS (0.47) | GUSBCTSLCTSSCTSKCTSB | |
| SCHEMBL6442129 | 0.83 | CTSL (0.49) | CTSL | |
| SCHEMBL6447506 | 0.82 | CTSL (0.53) | CTSLCTSSCTSKCTSVCTSB | |
| SCHEMBL6446816 | 0.81 | GAA (0.40) | GUSBCTSLCTSSCTSKCTSV | |
| SCHEMBL6442019 | 0.80 | CTSS (0.42) | GUSBCTSLCTSSCTSKCTSB | |
| SCHEMBL6020870 | 0.80 | CTSL (0.61) | CTSLCTSSCTSKCTSVCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | claimed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | claimed |
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | claimed |
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | disclosed |
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | disclosed |