Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 6/20 | 0.42 |
| ▸ | CTSK | P43235 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 6/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 3/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.37 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6443632 | 0.90 | SFN (0.42) | CTSSCTSKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6444782 | 0.90 | CTSK (0.53) | CTSSCTSKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6443588 | 0.90 | NPC1 (0.51) | CTSSCTSKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6446599 | 0.88 | GUSB (0.43) | CTSSCTSKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6446797 | 0.88 | CTSS (0.43) | CTSSCTSKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6443745 | 0.83 | CTSS (0.47) | CTSSCTSKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6445311 | 0.83 | ALDH1A1 (0.47) | CTSSCTSKSMN1; SMN2CTSLPOLB | |
| SCHEMBL6443534 | 0.81 | HDAC6 (0.37) | CTSSCTSKSMN1; SMN2CTSLGUSB | |
| SCHEMBL6446405 | 0.81 | CTSL (0.50) | CTSSCTSKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6445190 | 0.80 | GUSB (0.40) | CTSSCTSKKDM4ACTSLGUSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | claimed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | claimed |
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | claimed |
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | disclosed |