SCHEMBL6446797

SCHEMBL6446797

N#CCCNC(=O)C(CNC(=O)c1ccc(CCl)cc1)c1ccc2ccccc2c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSS P25774 3/20 0.43
CTSK P43235 3/20 0.43
CTSL P07711 2/20 0.43
CTSB P07858 1/20 0.43
ATM Q13315 1/20 0.41
HDAC1 Q13547 7/20 0.40
HDAC3 O15379 6/20 0.39
HDAC2 Q92769 6/20 0.39
HDAC4 P56524 5/20 0.39
HDAC7 Q8WUI4 5/20 0.39
HDAC10 Q969S8 5/20 0.39
HDAC11 Q96DB2 5/20 0.39
HDAC8 Q9BY41 5/20 0.39
HDAC6 Q9UBN7 5/20 0.39
HDAC9 Q9UKV0 5/20 0.39
HDAC5 Q9UQL6 5/20 0.39
NR1H4 Q96RI1 1/20 0.38
BCHE P06276 1/20 0.37
ACHE P22303 1/20 0.37
RAB9A P51151 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6446578 0.90 ATM (0.41) CTSSCTSKCTSLCTSBATM
SCHEMBL6446493 0.90 CTSL (0.53) CTSSCTSKCTSLCTSBATM
SCHEMBL6447322 0.90 CTSK (0.42) CTSSCTSKCTSLCTSBATM
SCHEMBL6442019 0.88 CTSS (0.42) CTSSCTSKCTSLCTSBRAB9A
SCHEMBL6443632 0.85 SFN (0.42) CTSSCTSKCTSLHDAC1HDAC3
SCHEMBL6443466 0.85 MEN1 (0.40) CTSSCTSKCTSLCTSBATM
SCHEMBL6446969 0.81 KDM4E (0.44) CTSSCTSKCTSLCTSBATM
SCHEMBL6447466 0.80 CTSL (0.47) CTSSCTSKCTSLCTSBATM
SCHEMBL6444201 0.80 CTSL (0.47) CTSLATMNPC1DRD2DRD3
SCHEMBL6447483 0.80 ATM (0.49) CTSSCTSKCTSLATMRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1575903-A1 COMPOUNDS FOR THE INHIBITION OF ROTAMASES Jerini AG (DE) 2005-09-21 EP claimed
WO-2004065353-A1 COMPOUNDS FOR THE INHIBITION OF ROTAMASES JERINI AG (DE) 2004-08-05 WO claimed
WO-2004056755-A2 COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES JERENI AG (DE) 2004-07-08 WO claimed
EP-1575903-A1 COMPOUNDS FOR THE INHIBITION OF ROTAMASES Jerini AG (DE) 2005-09-21 EP disclosed
WO-2004065353-A1 COMPOUNDS FOR THE INHIBITION OF ROTAMASES JERINI AG (DE) 2004-08-05 WO disclosed
WO-2004056755-A2 COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES JERENI AG (DE) 2004-07-08 WO disclosed