Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.51 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2264852 | 0.84 | ALDH1A1 (0.55) | ALDH1A1TAS1R3TAS1R1TSHRNPSR1 | |
| Hydrochloric Acid SCHEMBL2267196 | 0.84 | ALDH1A1 (0.54) | ALDH1A1TAS1R3TAS1R1TSHRNPSR1 | |
| SCHEMBL6501353 | 0.83 | L3MBTL1 (0.50) | ALDH1A1TSHRHPGDKMT2AMAPT | |
| SCHEMBL13556407 | 0.83 | ALDH1A1 (0.58) | ALDH1A1TAS1R3TAS1R1TSHRNPSR1 | |
| SCHEMBL12961919 | 0.81 | ALDH1A1 (0.54) | ALDH1A1TAS1R3TAS1R1TSHRNPSR1 | |
| SCHEMBL2267405 | 0.80 | ALDH1A1 (0.52) | ALDH1A1TAS1R3TAS1R1TSHRNPSR1 | |
| SCHEMBL3361891 | 0.77 | APLNR (0.63) | ALDH1A1TAS1R3TAS1R1TSHRNPSR1 | |
| SCHEMBL2267394 | 0.77 | MAPT (0.52) | ALDH1A1TAS1R3TAS1R1TSHRNPSR1 | |
| SCHEMBL6497717 | 0.77 | KDM4C (0.49) | ALDH1A1TAS1R3TAS1R1TSHRNPSR1 | |
| SCHEMBL4886080 | 0.74 | ROCK2 (0.63) | ALDH1A1TAS1R3TAS1R1TSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | PHARMACIA AND UPJOHN COMPANY LLC | 2005-09-08 | — | — | US | disclosed |
| WO-2005037797-A1 | SUBSTITUTED PYRAZOLE UREA COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2005-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | IL4, ARG2, CASP4 | ALDH1A1 846/4885TAS1R3 425/4885TAS1R1 597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.