Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 3/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.38 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.38 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.38 |
| ▸ | SLC6A11 | P48066 | 2/20 | 0.38 |
| ▸ | SLC6A13 | Q9NSD5 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.38 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.38 |
| ▸ | CPN1 | P15169 | 1/20 | 0.37 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRE | P78334 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL28068286 | 0.90 | SLC6A1 (0.47) | GABRA5GABRB2SLC6A1SLC6A12SLC6A11 | |
| Trifluoroacetic Acid SCHEMBL6475932 | 0.85 | GABRA5 (0.37) | GABRA5GABRB2SLC6A1SLC6A12SLC6A11 | |
| Trifluoroacetic Acid SCHEMBL27683337 | 0.84 | HSD11B1 (0.37) | HSD11B1 | |
| SCHEMBL123988 | 0.81 | — | — | |
| Propionic Acid SCHEMBL27300730 | 0.81 | GABRA5 (0.43) | GABRA5GABRB2SLC6A1SLC6A12SLC6A11 | |
| Trifluoroacetic Acid SCHEMBL28525241 | 0.79 | HSD11B1 (0.38) | CPB2HSD11B1KDM1AF2 | |
| Trifluoroacetic Acid SCHEMBL15654913 | 0.79 | HSD11B1 (0.38) | CPB2HSD11B1KDM1AF2 | |
| Hydrochloric Acid SCHEMBL1978311 | 0.79 | SLC6A2 (0.35) | GABRA5GABRB2SLC6A1SLC6A12SLC6A11 | |
| Trifluoroacetic Acid SCHEMBL35211020 | 0.77 | CHRNB2 (0.35) | KDM1A | |
| Trifluoroacetic Acid SCHEMBL334563 | 0.77 | GABRP (0.39) | GABRA5GABRB2GABRA1GABRA4CPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12478620-B2 | Cyano-substituted cyclic hydrazine derivative and application thereof | E-NITIATE BIOPHARMACEUTICALS (HANGZHOU) CO., LTD (CN) | 2025-11-25 | — | — | US | disclosed |
| US-20220339146-A1 | CYANO-SUBSTITUTED CYCLIC HYDRAZINE DERIVATIVE AND APPLICATION THEREOF | E-NITIATE BIOPHARMACEUTICALS (HANGZHOU) CO., LTD (CN) | 2022-10-27 | — | — | US | disclosed |
| EP-4032888-A1 | CYANO-SUBSTITUTED CYCLIC HYDRAZINE DERIVATIVE AND APPLICATION THEREOF | E-nitiate Biopharmaceuticals (Hangzhou) Co., Ltd (CN) | 2022-07-27 | — | — | EP | disclosed |
| CN-110483514-B | Cyano-substituted cyclic hydrazine derivative and application thereof | 启元生物(杭州)有限公司 | 2022-06-14 | — | — | CN | disclosed |
| WO-2021051899-A1 | CYANO-SUBSTITUTED CYCLIC HYDRAZINE DERIVATIVE AND APPLICATION THEREOF | 维眸生物科技（上海）有限公司 | 2021-03-25 | — | — | WO | disclosed |
| CN-110483514-A | The ring hydrazine derivate and its application that a kind of cyano replaces | VIVAVISION BIOPHARMA SHANGHAI CO LTD | 2019-11-22 | — | — | CN | disclosed |
| US-6962911-B2 | Pyrrolopyrimidinone derivatives, process of preparation and use | SK CHEMICALS CO., LTD. (KR) | 2005-11-08 | — | — | US | disclosed |
| EP-1257553-B1 | PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE | SK CHEMICALS CO LTD (KR) | 2004-05-26 | — | — | EP | disclosed |
| US-20030171361-A1 | Pyrrolopyrimidinone derivatives, process of preparation and use | SK CHEMICALS CO., LTD. (KR) | 2003-09-11 | — | — | US | disclosed |
| EP-1257553-A1 | PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE | SK Chemicals Co., Ltd. (KR) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001060825-A1 | PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE | SK CHEMICALS CO., LTD. (KR) | 2001-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171361-A1 | Pyrrolopyrimidinone derivatives, process of preparation and use | CYP2C19, DHPS, SDHA | GABRA5 2467/4885GABRB2 3491/4885SLC6A1 3871/4885 |
| US-20220339146-A1 | CYANO-SUBSTITUTED CYCLIC HYDRAZINE DERIVATIVE AND APPLICATION THEREOF | WNK1, STK35, CDK1 | GABRA5 3532/4885GABRB2 4091/4885SLC6A1 1140/4885 |
| US-12478620-B2 | Cyano-substituted cyclic hydrazine derivative and application thereof | WNK1, STK35, CDK1 | GABRA5 3532/4885GABRB2 4091/4885SLC6A1 1140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.