Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT1 | P34896 | 3/20 | 0.36 |
| ▸ | SHMT2 | P34897 | 3/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | CYP2J2 | P51589 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 8/20 | 0.34 |
| ▸ | CNR2 | P34972 | 4/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6506148 | 0.91 | KMT2A (0.38) | APPACACBMEN1HTTKMT2A | |
| SCHEMBL6497551 | 0.90 | P2RX3 (0.37) | APPACACBMEN1HTTKMT2A | |
| SCHEMBL7684255 | 0.89 | SHMT1 (0.40) | SHMT1SHMT2CYP2C9CNR1CNR2 | |
| SCHEMBL6496054 | 0.88 | KDM4E (0.40) | SHMT1SHMT2CYP2C9CNR1ACACB | |
| SCHEMBL6495943 | 0.85 | FFAR1 (0.39) | APPACACBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL6496508 | 0.80 | FFAR2 (0.35) | CNR2KDM4EMAPTMEN1HTT | |
| SCHEMBL6505584 | 0.78 | DGAT1 (0.38) | ACACBKDM4EMAPTMEN1KMT2A | |
| SCHEMBL6503012 | 0.77 | MAPT (0.39) | ACACBMAPTMEN1KMT2ARXFP1 | |
| SCHEMBL6495548 | 0.77 | TP53 (0.40) | ACACBMAPTMEN1KMT2AGAA | |
| SCHEMBL6496225 | 0.76 | WDR5 (0.36) | SHMT1SHMT2EPHX2CYP2C9CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |