SCHEMBL7684255

SCHEMBL7684255

Cc1sc(-c2ccc(Cl)cc2Cl)nc1C(=O)NCC(c1ccc(OC(C)C)cc1)C(OC(C)C)C(=O)O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SHMT1 P34896 6/20 0.40
SHMT2 P34897 4/20 0.40
KDM4E B2RXH2 2/20 0.37
MAPT P10636 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.36
CYP2C9 P11712 2/20 0.36
CYP2C19 P33261 2/20 0.36
ALDH1A1 P00352 1/20 0.36
GAA P10253 1/20 0.36
HPGD P15428 1/20 0.36
DAGLA Q9Y4D2 2/20 0.36
ALPL P05186 1/20 0.35
CNR1 P21554 4/20 0.34
USP36 Q9P275 1/20 0.33
CTSA P10619 1/20 0.33
CNR2 P34972 1/20 0.33
LMNA P02545 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6496054 0.92 KDM4E (0.40) SHMT1SHMT2KDM4EMAPTSMN1; SMN2
SCHEMBL6496508 0.90 FFAR2 (0.35) KDM4EMAPTSMN1; SMN2ALDH1A1GAA
SCHEMBL6496229 0.89 SHMT1 (0.36) SHMT1SHMT2KDM4EMAPTSMN1; SMN2
SCHEMBL7676306 0.83 MAPT (0.42) KDM4EMAPTALDH1A1GAAHPGD
SCHEMBL6505584 0.82 DGAT1 (0.38) KDM4EMAPTSMN1; SMN2ALDH1A1GAA
SCHEMBL6495786 0.79 NPC1 (0.38) SMN1; SMN2ALDH1A1GAALMNANPSR1
SCHEMBL6497551 0.78 P2RX3 (0.37) SMN1; SMN2GAAHTT
SCHEMBL6503799 0.76 EGLN2 (0.35) KDM4EMAPTSMN1; SMN2ALDH1A1
SCHEMBL6504635 0.76 MAPT (0.47) MAPTSMN1; SMN2ALDH1A1HPGDLMNA
SCHEMBL7684246 0.73 SHMT1 (0.39) SHMT1SHMT2KDM4EMAPTCNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1216980-A1 CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME Eisai Co., Ltd. (JP) 2002-06-26 EP disclosed