Sugi Predict

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SCHEMBL6500495

SCHEMBL6500495

CC(C)(C)OC(=O)N1CCCNCC1c1ccc(NC(=O)OCc2ccccc2)cc1F

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ MGLL Q99685 3/20 0.41
▸ PTGDR2 Q9Y5Y4 1/20 0.40
▸ PDE3B Q13370 1/20 0.40
▸ PDE3A Q14432 1/20 0.40
▸ RORC P51449 2/20 0.40
▸ NPC1 O15118 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ TP53 P04637 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ ATM Q13315 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ USP30 Q70CQ3 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4688897 0.86 MGLL (0.46) MGLLPTGDR2NPC1ALDH1A1TP53
SCHEMBL5206161 0.77 NR1H2 (0.42) MAPTTSHR
SCHEMBL8552629 0.76 SIGMAR1 (0.48) MGLL
SCHEMBL6510132 0.75 NPY2R (0.52) PTGDR2NPC1ALDH1A1TP53MAPT
SCHEMBL31639792 0.74 ALDH1A1 (0.47) MGLLALDH1A1TP53USP30
SCHEMBL30968474 0.74 CA1 (0.44) RORCALDH1A1MAPTTSHR
SCHEMBL5724950 0.74 FKBP1A (0.43) NPC1ALDH1A1MAPTRAB9A
SCHEMBL31333270 0.74 ALDH1A1 (0.45) NPC1ALDH1A1TP53RAB9ASMN1; SMN2
SCHEMBL1338682 0.73 NPC1 (0.48) MGLLNPC1ALDH1A1TP53MAPT
SCHEMBL8347802 0.73 MGLL (0.47) MGLLNPC1ALDH1A1TP53MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6956040-B2 Oxazolidinone piperazinyl derivatives as potential antimicrobials RANBAXY LABORATORIES LIMITED (IN) 2005-10-18 — — US disclosed
US-20040254162-A1 Oxazolidinone derivatives as antimicrobials RANBAXY LABORATORIES LIMITED (IN) 2004-12-16 — — US disclosed
US-6734307-B2 USE AGAINST MULTIPLY RESISTANT GRAM POSITIVE PATHOGENS; HAVE A DIAZINE MOIETY ATTACHED TO THE PHENYLOXAZOLIDINONE WHICH IS FURTHER SUBSTITUTED BY HETEROCYCLIC, ARYL, SUBSTITUTED ARYL, HETEROAROAMATIC RING RANBAXY LABORATORIES LIMITED (IN) 2004-05-11 — — US disclosed
US-20030119817-A1 Oxazolidinone derivatives as potential antimicrobials MEHTA ANITA (IN) 2003-06-26 — — US disclosed
US-20020103186-A1 Oxazolidinone derivatives as antimicrobials disease RANBAXY LABORATORIES LIMITED (IN) 2002-08-01 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030119817-A1 Oxazolidinone derivatives as potential antimicrobials OXA1L, PDK4, SDHA MGLL 2465/4885PTGDR2 2944/4885PDE3B 3394/4885
US-20020103186-A1 Oxazolidinone derivatives as antimicrobials disease OXA1L, MLYCD, TBCD MGLL 2306/4885PTGDR2 2986/4885PDE3B 3711/4885
US-20040254162-A1 Oxazolidinone derivatives as antimicrobials PPARD, PDK4, OXA1L MGLL 2119/4885PTGDR2 2699/4885PDE3B 3387/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.