Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6499003 | 0.92 | HPGD (0.37) | HPGDRAB9AP2RX7ALDH1A1NPC1 | |
| SCHEMBL6505057 | 0.92 | HPGD (0.48) | HPGDRAB9AP2RX7KLKB1NPC1 | |
| SCHEMBL6497497 | 0.90 | S1PR3 (0.38) | HPGDRAB9AP2RX7EPHX2MEN1 | |
| Trifluoroacetic Acid SCHEMBL6504858 | 0.88 | HPGD (0.40) | HPGDRAB9AP2RX7PTGDRALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL6498995 | 0.81 | PPARG (0.39) | HPGDRAB9AALDH1A1NPC1TP53 | |
| Trifluoroacetic Acid SCHEMBL6505054 | 0.80 | HPGD (0.49) | HPGDRAB9AP2RX7ALDH1A1KLKB1 | |
| Trifluoroacetic Acid SCHEMBL6497487 | 0.79 | S1PR3 (0.40) | — | |
| SCHEMBL6504395 | 0.78 | PPARA (0.37) | P2RX7KLKB1MAPTSMN1; SMN2 | |
| SCHEMBL6505593 | 0.78 | ADORA2A (0.35) | HPGDRAB9AALDH1A1NPC1POLB | |
| SCHEMBL6494741 | 0.78 | PPARA (0.39) | MAPTMEN1KMT2APOLBHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |